scispace - formally typeset
Search or ask a question
Topic

Surface plasmon resonance

About: Surface plasmon resonance is a research topic. Over the lifetime, 24909 publications have been published within this topic receiving 810976 citations. The topic is also known as: Surface plasmon resonance & SPR (technology).


Papers
More filters
Journal ArticleDOI
TL;DR: Theoretical analysis of the sensitivity of surface plasmon resonance (SPR) sensors with spectral interrogation is presented in this article, where two basic configurations of SPR sensors are investigated for the measurement of variations in the refractive index of bulk media, and for the monitoring of variation in the thickness of thin films.
Abstract: Theoretical analysis of the sensitivity of surface plasmon resonance (SPR) sensors with spectral interrogation is presented. Two basic configurations of SPR sensors with spectral interrogation are investigated—for the measurement of variations in the refractive index of bulk media, and for the monitoring of variations in the thickness of thin films. In both cases, analytical expressions allowing the sensitivity of SPR sensors to be calculated are derived and validated. On the basis of the theoretical analysis, the optimization of a spectral SPR sensor in terms of the operation wavelength and the choice of metal layer is carried out. It is demonstrated that spectral SPR sensors may attain higher sensitivity if operating at longer wavelengths and if using metal layers with a higher modulus of the real part of the dielectric constant.

345 citations

Journal ArticleDOI
TL;DR: It is anticipated that the direct label-free optical immunoassay of proteins reported here will revolutionize clinical diagnosis and accelerate the development of hand-held and user-friendly point-of-care devices.
Abstract: In this research, a localized surface plasmon resonance (LSPR)-based bioanalysis method for developing multiarray optical nanochip suitable for screening bimolecular interactions is described. LSPR-based label-free monitoring enables to solve the problems of conventional methods that require large sample volumes and time-consuming labeling procedures. We developed a multiarray LSPR-based nanochip for the label-free detection of proteins. The multiarray format was constructed by a core-shell-structured nanoparticle layer, which provided 300 nanospots on the sensing surface. Antibodies were immobilized onto the nanospots using their interaction with Protein A. The concentrations of antigens were determined from the peak absorption intensity of the LSPR spectra. We demonstrated the capability of the array measurement using immunoglobulins (IgA, IgD, IgG, IgM), C-reactive protein, and fibrinogen. The detection limit of our label-free method was 100 pg/mL. Our nanochip is readily transferable to monitor the interactions of other biomolecules, such as whole cells or receptors, with a massively parallel detection capability in a highly miniaturized package. We anticipate that the direct label-free optical immunoassay of proteins reported here will revolutionize clinical diagnosis and accelerate the development of hand-held and user-friendly point-of-care devices.

345 citations

Journal ArticleDOI
TL;DR: Sulfur‐based molecules containing biotin and hydroxyl groups have been used to create a wide variety of self‐assembled monolayer on gold surfaces to study in situ the binding of streptavidin to these monolayers from solution.
Abstract: Sulfur‐based molecules containing biotin and hydroxyl groups have been used to create a wide variety of self‐assembled monolayers on gold surfaces. Surface plasmon resonance has been used to study in situ the binding of streptavidin to these monolayers from solution. The self‐assembled monolayers allow a high degree of control over the surface properties. The choice of an appropriate biotin‐containing molecule, with a spacer segment, and the dilution of this molecule within the monolayer by hydroxythiols, allows optimization of the binding properties of the monolayer—nonspecific interactions between streptavidin and the surface are below detection limits, and specific binding between the streptavidin and biotin groups can be maximized.

344 citations

Journal ArticleDOI
TL;DR: The in situ monitoring of the step-by-step formation of metal-organic frameworks (MOFs) by using surface plasmon resonance (SPR) allows the nucleation process and the formation of the secondary building units to be investigated.
Abstract: One step at a time: The in situ monitoring of the step-by-step formation of metal-organic frameworks (MOFs) by using surface plasmon resonance (SPR), allows the nucleation process and the formation of the secondary building units to be investigated. Growth rates on functionalized organic surfaces with different crystallographic orientations can also be studied.

343 citations

Journal ArticleDOI
14 May 2009-ACS Nano
TL;DR: A comprehensive theoretical analysis that examines the geometric plasmon tunability over a range of core permittivities enables us to identify the dielectric properties of the mixed oxide magnetic core directly from the plAsmonic behavior of the core-shell nanoparticle.
Abstract: Nanoparticles composed of magnetic cores with continuous Au shell layers simultaneously possess both magnetic and plasmonic properties. Faceted and tetracubic nanocrystals consisting of wustite with magnetite-rich corners and edges retain magnetic properties when coated with a Au shell layer, with the composite nanostructures showing ferrimagnetic behavior. The plasmonic properties are profoundly influenced by the high dielectric constant of the mixed iron oxide nanocrystalline core. A comprehensive theoretical analysis that examines the geometric plasmon tunability over a range of core permittivities enables us to identify the dielectric properties of the mixed oxide magnetic core directly from the plasmonic behavior of the core−shell nanoparticle.

341 citations


Network Information
Related Topics (5)
Nanoparticle
85.9K papers, 2.6M citations
92% related
Graphene
144.5K papers, 4.9M citations
91% related
Carbon nanotube
109K papers, 3.6M citations
90% related
Raman spectroscopy
122.6K papers, 2.8M citations
90% related
Thin film
275.5K papers, 4.5M citations
86% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20231,320
20222,684
20211,240
20201,422
20191,498
20181,528