Topic
Synaptonemal complex
About: Synaptonemal complex is a research topic. Over the lifetime, 1952 publications have been published within this topic receiving 91778 citations. The topic is also known as: GO:0000795.
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TL;DR: Findings suggest a functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles, which, in turn, suggests a role for BRC a1 in the control of recombination and of genome integrity.
1,484 citations
TL;DR: The current article reviews recent information on diverse aspects of chromosome morphogenesis, notably relationships between sisters, development of axial structure, and variations in chromatin status in an historical context.
Abstract: ▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the fundamental life processes they represent, but also because meiosis involves the formation of homolog pairs, ...
1,206 citations
TL;DR: DMC1 phenotypes provide further evidence that recombination and SC formation are interrelated processes and are consistent with a requirement for DNA-DNA interactions during SC formation, and additional evidence suggests that arrest occurs at a meiosis-specific cell cycle "checkpoint" in response to a primary defect in prophase chromosome metabolism.
1,142 citations
TL;DR: It is found that a homolog of the yeast DSB-generating enzyme, Spo11p, is required for meiotic exchange in this metazoan, and that radiation-induced breaks partially alleviate this dependence, suggesting initiation of recombination by DSBs is apparently conserved.
772 citations
TL;DR: The results support the view that mammalian checkpoint responses to meiotic recombination and/or synapsis defects are sexually dimorphic and propose that recombination initiation precedes and is required for normalsynapsis in mammals.
679 citations