Topic
Tartrate-resistant acid phosphatase
About: Tartrate-resistant acid phosphatase is a research topic. Over the lifetime, 1115 publications have been published within this topic receiving 45937 citations. The topic is also known as: HPAP & SPENCDI.
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TL;DR: The uterine glands, glandular secretions and areolar chorionic epithelium of the pig placenta in late gestation show high levels of histochemical phosphatase activity at acid pH, particularly towards aromatic monophosphates.
4 citations
Journal Article•
TL;DR: Two premenopausal women with rheumatoid arthritis of 16 years' duration were enrolled in a one year conditioning exercise program consisting of walking and low impact aerobics and the effect of exercise on the markers of bone formation, bone resorption, and vertebral bone mineral density are discussed.
Abstract: Two premenopausal women with rheumatoid arthritis of 16 years' duration were enrolled in a one year conditioning exercise program consisting of walking and low impact aerobics. The effect of exercise on the markers of bone formation (serum bone specific alkaline phosphatase and osteocalcin), bone resorption (urinary calcium/creatine and serum tartrate resistant acid phosphatase), and vertebral bone mineral density as determined by dual photon absorptiometry are discussed.
4 citations
TL;DR: Alkaline fixation-resistant acid phosphatase appears to represent a previously unknown or uncharacterized enzyme activity whose chemical properties could not be classified as any previously known type of acid or other phosphatases.
Abstract: The effect of pH during formalin fixation on acid phosphatases in human tissues was studied. Lysosomal-type acid phosphatase was sensitive to alkaline fixation, being completely inactive after fixation at pH 9.0. Prostatic and tartrate-resistant osteoclastic/macrophagic types were alkaline fixation-resistant, as was an acid phosphatase localized in endothelium, endometrial stromal cells and intestinal nerves. The latter activity was further separable into fluoride- and tartrate-sensitive β-glycerophosphatase and fluoride-sensitive, tartrate-resistant α-naphthyl phosphatase. The activities appeared to represent either different, tightly associated enzymes or separate activity centres of a single enzyme. Alkaline fixation-resistant α-naphthyl phosphatase at endothelial, endometrial and neuronal sites was also well demonstrated in unfixed or neutral formalin-fixed sections as tartrate-resistant activity similar to classical tartrate-resistant acid phosphatase, but these phosphatases appear to be antigenically different. Alkaline fixation-resistant acid phosphatase showed a restricted tissue distribution both in endothelium (mainly in vessels of abdominal organs) and at neuronal sites (only in intestinal nerves). Alkaline fixation-resistant acid phosphatase appears to represent a previously unknown or uncharacterized enzyme activity whose chemical properties could not be classified as any previously known type of acid or other phosphatases.
4 citations
TL;DR: BSZGC can inhibit the proliferation of the osteoclasts and reduce TRACP activity, which may be one of the mechanisms of its preventive and therapeutic actions on osteoporosis.
4 citations
TL;DR: A study was carried out to determine if an initial measurement of serum tartrate‐resistant acid phosphatase would be predictive of bone mass loss quantified by dual‐energy X‐ray absorptiometry, as total bone mineral content and total bone Mineral content corrected for weight.
Abstract: Background A study was carried out over a 24-month interval to determine if an initial measurement of serum tartrate-resistant acid phosphatase would be predictive of bone mass loss quantified by dual-energy X-ray absorptiometry, as total bone mineral content and total bone mineral content corrected for weight.
Design Sixty-two women were studied (at onset: mean age 59·7 ± 8·9 years, 10·8 ± 8·8 years since menopause; at conclusion: mean age 61·9 ± 8·8 and 13·0 ± 8·7 since menopause).
Results A paired Wilcoxon test showed a small, but significant, increase in weight (P < 0·05) and decrease in height (P < 0·05). Total bone mineral content and total bone mineral content corrected for weight decreased (P < 0·005 and 0·0001, respectively). Serum tartrate-resistant acid phosphatase increased (P < 0·005). Single-regression analysis showed that the per cent bone mass loss observed between the first and second body bone mineral content measurements correlated negatively with the first serum tartrate-resistant acid phosphatase determination (r = −0·62, P < 0·0001). Changes in tartrate-resistant acid phosphatase correlated negatively with changes in total bone mineral content (r = −0·79, P < 0·0001). In a multiple regression analysis of per cent change in bone mass against initially important variables such as age, years since menopause, weight, and tartrate-resistant acid phosphatase, only tartrate-resistant acid phosphatase was significant (P < 0·0001). The sensitivity and specifity of tartrate-resistant acid phosphatase for evaluating bone loss were 86% and 78%, respectively, and the area under the curve was of 0·83 (95% CI 0·71–0·95).
Conclusion These results show that a simple measurement of serum tartrate-resistant acid phosphatase can help to predict the potential rate of bone mass loss in women.
4 citations