Topic
Tartrate-resistant acid phosphatase
About: Tartrate-resistant acid phosphatase is a research topic. Over the lifetime, 1115 publications have been published within this topic receiving 45937 citations. The topic is also known as: HPAP & SPENCDI.
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TL;DR: Tanshinone IIA has the potential to ameliorate bone-resorption diseases in vivo by reducing both the number and activity of osteoclasts.
71 citations
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TL;DR: Results strongly suggest that anti–FRP‐1 antibody‐induced multinucleated cells are osteoclasts, as FRP‐ 1 antigens were detected in osteoclast isolated from human bone and in the osteoclast‐like cells obtained from human giant cell tumors of bone.
Abstract: We have developed a new and simple system of human osteoclast formation by fusing peripheral blood monocytes with anti-Fusion Regulatory Protein-1 (anti-FRP-1) monoclonal antibody (mAb). When human blood monocytes were cultured in the presence of anti-FRP-1/CD98 mAbs, polykaryocytes began to appear at approximately 15 h and increased in size with time until 3-4 days of incubation with anti-FRP-1 mAb. These fused cells showed positive staining in tartrate-resistant acid phosphatase, possessed numerous calcitonin receptors, and were capable of bone resorption. These results strongly suggest that anti-FRP-1 antibody-induced multinucleated cells are osteoclasts. Furthermore, FRP-1 antigens were detected in osteoclasts isolated from human bone and in the osteoclast-like cells obtained from human giant cell tumors of bone.
70 citations
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TL;DR: Functional differences between bone-resorbing clasts within the trabecular metaphyseal bone are highlighted, suggesting potentially important differences in the regulation of differentiation and activation depending on the precise anatomical localization of the clast population.
70 citations
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TL;DR: Evidence is presented that the change in the adhesion of osteoclasts from the periosteum to the bone surface, resulting in osteoclast activation, is mediated by OPGL.
70 citations
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TL;DR: Evaluating the effect of Tumor necrosis factor-alpha (TNF-α) on RANKL expression in bone marrow adipocytes, and osteoclast differentiation supported by human bone marrow fatocytes found TNF- α induced the ability of bone marrow lipidocytes to promote osteOClast differentiation and activity in a manner directly related to RankL expression.
69 citations