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Showing papers on "Taspine published in 2010"


Journal ArticleDOI
Jie Zhang1, Yanmin Zhang1, Yuanyuan Shan1, Na Li1, Wei Ma1, Langchong He1 
TL;DR: A series of novel taspine derivatives were synthesized and screened for in vitro anticancer and antiangiogenesis activities and demonstrated a moderate degree of cytotoxicity against human cancer cell lines.

44 citations


Journal ArticleDOI
Jie Zhang1, Yanmin Zhang1, San-Qi Zhang1, Sicen Wang1, Langchong He1 
TL;DR: The design, synthesis, and preliminary evaluation of four novel taspine derivatives as VEGFR-2 inhibitors are reported, and the preliminary biological test showed that one of the compounds showed much better inhibitory activities against CACO-2 and ECV304 than taspin.

28 citations


Journal ArticleDOI
Yali Zhou1, Wenjuan Luo1, Lei Zheng1, Miao Li1, Yanmin Zhang1 
01 Jul 2010-Plasmid
TL;DR: It is demonstrated that taspine can down-regulate phosphorylation of FGFR1 and ERK, and inhibit Hek293/FG FR1 and MCF-7 cell proliferation.

20 citations


Journal ArticleDOI
TL;DR: In this paper, a nonaqueous capillary electrophoresis (NACE) method has been developed for the simultaneous determination of magnoflorine, taspine, and caulophine in Caulophyllum robustum collected in different seasons.
Abstract: A non-aqueous capillary electrophoresis (NACE) method has been developed for the simultaneous determination of magnoflorine, taspine, and caulophine in Caulophyllum robustum collected in different seasons. The relative standard deviations (RSDs) of the migration times and peak areas of the three components were 0.33 and 3.34% for magnoflorine, 0.45 and 2.67% for taspine, and 0.49 and 3.71% for caulophine, respectively. Detection limits of magnoflorine, taspine, and caulophine were 0.30 μg/mL, 0.08 μg/mL, and 0.10 μg/mL, respectively. This method has been successfully applied to simultaneous determination of the three bioactive components in the different collection seasons.

5 citations