Showing papers on "Taspine published in 2013"
DOI•
13 Nov 2013TL;DR: In this article, the authors summarized the most important research findings regarding the applications of Croton lechleri extract. But, they did not consider the safety testing and clinical trials of these compounds.
Abstract: Plants of the amazon region are commonly applied for medicinal uses, foremost among these is the latex producing Croton lechleri. The taspine rich latex has anti-inflammatory, wound healing, and soothing properties, among several others. This review summarizes the most important research findings regarding the applications of this plant extract. Public receptiveness to plant based treatments result in indiscriminate use of these compounds, often with no scientific validation. Likewise, Croton lechleri extracts must be subjected to safety testing and clinical trials before its products are made available, in a commercial scale, with recognized therapeutic functions. Key words: Herbal, Croton lecheri, taspine, update.
9 citations
TL;DR: In this paper, the total synthesis of taspine, starting from ferulic acid and isovanillin, was reported, and the successful synthetic strategy was then applied to the synthesis of a symmetrical analogue TAS2C.
6 citations
TL;DR: Results revealed that tas1611 had a marked inhibitory effect on the invasion of the SMMC-7721 cells and that this effect was associated with the activity and expression levels of matrix metalloproteinase (MMP)-2 and MMP-9.
Abstract: Taspine is an attractive target of research due to the anticancer and anti-angiogenic effects shown by in vitro and in vivo experiments. The present study investigated the role of tas1611, which is a derivative of taspine that has increased activity and solubility, in the regulation of the invasive properties of the SMMC-7721 liver cell line in vitro and in tumor inhibition in vivo. The proliferation of the SMMC-7721 cells was examined using the tetrazole blue colorimetric method. Matrigel® invasion chamber assays and zymogram analyses were performed to assess the inhibitory effect of tas1611 on cell invasion. Finally, a solid tumor athymic mouse model was employed to further investigate the anti-tumor effect of this compound. The results revealed that tas1611 had a marked inhibitory effect on the invasion of the SMMC-7721 cells and that this effect was associated with the activity and expression levels of matrix metalloproteinase (MMP)-2 and MMP-9. Furthermore, tas1611 was able to inhibit tumor growth effectively in a solid tumor SMMC-7721 athymic mouse model. In conclusion, tas1611 may serve as a promising novel therapeutic candidate for the treatment of metastatic liver cancer.
3 citations
Patent•
06 May 2013
TL;DR: In this article, a cosmetic composition containing a Croton Lechleri resin extract is provided to improve skin moisturization, elasticity, antiaging, and skin whitening, and to ensure antibacterial and anti-inflammatory effects.
Abstract: PURPOSE: A cosmetic composition containing a Croton Lechleri resin extract is provided to improve skin moisturization, elasticity, anti-aging, and skin whitening, and to ensure antibacterial and anti-inflammatory effects. CONSTITUTION: A cosmetic composition contains 0.0001-20 wt% of a Croton Lechleri resin extract as an active ingredient. The extract contains proanthocyanidin and taspine as active ingredients. The extract is prepared by leaching Croton Lechleri resin in water or an organic solvent, purifying, and extracting. [Reference numerals] (AA) Example 1; (BB) Comparative example 1; (CC) 0 week; (DD) 2 weeks; (EE) 4 weeks
3 citations