Topic
Taspine
About: Taspine is a research topic. Over the lifetime, 73 publications have been published within this topic receiving 1377 citations.
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20 Sep 1990
TL;DR: A wound healing composition is a pharmaceutical dosage unit form including a wound-healing amount of an aporphinoid alkaloid such as taspine free acid, dissolved in a physiologically tolerable nonaqueous solvent such as dimethylsulfoxide as discussed by the authors.
Abstract: A wound healing composition is a pharmaceutical dosage unit form including a wound-healing amount of an aporphinoid alkaloid such as taspine free acid, dissolved in a physiologically tolerable non-aqueous solvent such as dimethylsulfoxide
23 citations
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TL;DR: This is the first report of two neolignans of spirocyclohexadienone skeleton and of taspine from the Magnoliaceae family and the second report of the natural occurrence of futoenone.
22 citations
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TL;DR: The results showed taspine could inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner and can induce its apoptosis.
21 citations
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TL;DR: The results indicated that the majority of the compounds exhibited anticancer activity equivalent to or greater than the positive control, and provided a good starting point for further development of symmetrical biphenyl derivatives as potential novel anticancer agents.
Abstract: It has been demonstrated that taspine derivatives act as anticancer agents, thus we designed and synthesized a novel class of symmetrical biphenyl derivatives. We evaluated the cytotoxicity and antitumor activity of biphenyls against five human tumor and normal cell lines. The results indicated that the majority of the compounds exhibited anticancer activity equivalent to or greater than the positive control. Compounds (11) and (12) demonstrated the most potent cytotoxic activity with IC50 values between 19.41 μM and 29.27 μM. The potent antiproliferative capabilities of these compounds against ECV304 human transformed endothelial cells indicated that these biphenyls could potentially serve as antiangiogenic agents. We also reviewed the relationship between structure and activity based on the experimental results. Our findings provide a good starting point for further development of symmetrical biphenyl derivatives as potential novel anticancer agents.
20 citations
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TL;DR: It is demonstrated that taspine can down-regulate phosphorylation of FGFR1 and ERK, and inhibit Hek293/FG FR1 and MCF-7 cell proliferation.
20 citations