Topic
TEC
About: TEC is a research topic. Over the lifetime, 5119 publications have been published within this topic receiving 84696 citations.
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TL;DR: A series of approaches for GNSS-based ionospheric remote sensing and software has been proposed and developed by the Institute of Geodesy and Geophysics (IGG) in Wuhan as discussed by the authors.
40 citations
Journal Article•
TL;DR: This review summarizes current knowledge concerning the in vivo roles of the Tec family proteins and reveals that Tec kinases regulate phospholipase C isoforms.
Abstract: The Tec family has emerged recently as a subfamily among nonreceptor type protein-tyrosine kinases, consisting of Tec, Btk, Itk/Tsk/Emt, Bmx, and Txk/Rlk Because many members of this family have been shown to be activated in response to growth and differentiation stimuli in hematopoietic tissues, they are presumed to function in vivo as important signaling mediators Although that hypothesis was further strengthened by the knowledge that mutations in Btk cause agammaglobulinemia in humans, we have only limited information concerning the molecular interaction through which Tec kinases exert their effects One characteristic feature of Tec family members is the presence of a pleckstrin homology domain in their protein structure, suggesting a physical and functional interaction with the phospholipid-dependent signaling pathways Recent data have revealed that Tec kinases regulate phospholipase C isoforms This review summarizes current knowledge concerning the in vivo roles of the Tec family proteins
40 citations
TL;DR: Tec kinase is a novel innate-specific inflammatory kinase, whose genetic ablation or inhibition by small molecule drugs strongly protects mice from fungal sepsis, and demonstrates a therapeutic potential for Tec kinase inhibition to combat invasive microbial infections by attenuating the host inflammatory response.
Abstract: Tec family kinases are intracellular non-receptor tyrosine kinases implicated in numerous functions, including T cell and B cell regulation. However, a role in microbial pathogenesis has not been described. Here, we identified Tec kinase as a novel key mediator of the inflammatory immune response in macrophages invaded by the human fungal pathogen C. albicans. Tec is required for both activation and assembly of the noncanonical caspase-8, but not of the caspase-1 inflammasome, during infections with fungal but not bacterial pathogens, triggering the antifungal response through IL-1β. Furthermore, we identify dectin-1 as the pathogen recognition receptor being required for Syk-dependent Tec activation. Hence, Tec is a novel innate-specific inflammatory kinase, whose genetic ablation or inhibition by small molecule drugs strongly protects mice from fungal sepsis. These data demonstrate a therapeutic potential for Tec kinase inhibition to combat invasive microbial infections by attenuating the host inflammatory response.
40 citations
01 Jan 2004
TL;DR: In this paper, the relationship between TEC and (foF2) 2 showed that although they are highly correlated, a "hys-teresis" effect exists between them.
Abstract: Investigation of the relationship between TEC and (foF2) 2 shows that although they are highly correlated, a «hys- teresis» effect exists between them. The slab thickness is greater before than after mid-day for equal cosχ val- ues. Moreover, a comparison of the calculated upper and lower quartiles of variability in TEC, foF2 and Nmax, respectively shows that the variability of TEC lies between those of foF2 and Nmax depending on the level of so- lar activity.
40 citations
Patent•
30 May 2008
TL;DR: In this article, a thermoelectric cooler (TEC) inside an insulated container is used to keep medical materials such as medicine, such as drugs, cool. But, the TEC is in contact with a freezable material, which is frozen when the tEC is electrically powered.
Abstract: The present invention provides a device for keeping medical materials, such as medicine, cool. The device allows for easy transportation provided infrequent access to electricity. The device incorporates a thermoelectric cooler (TEC) inside an insulated container. The TEC is in contact with a freezable material which is frozen when the TEC is electrically powered. Upon disconnect from electrical power, the freezable material provides passive cooling inside the container while the medical material is transported. This portable device helps patients to travel with their medicines confidently and safely.
40 citations