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TEC

About: TEC is a research topic. Over the lifetime, 5119 publications have been published within this topic receiving 84696 citations.


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Journal ArticleDOI
TL;DR: It is suggested that blockage of TEC MCP-1 expression is a therapeutic strategy for some forms of kidney disease.
Abstract: Monocyte chemoattractant protein-1 (MCP-1) is upregulated in renal parenchymal cells during kidney disease. To investigate whether MCP-1 promotes tubular and/or glomerular injury, we induced nephrotoxic serum nephritis (NSN) in MCP-1 genetically deficient mice. Mice were analyzed when tubules and glomeruli were severely damaged in the MCP-1–intact strain (day 7). MCP-1 transcripts increased fivefold in MCP-1–intact mice. MCP-1 was predominantly localized within cortical tubules (90%), and most cortical tubules were damaged, whereas few glomerular cells expressed MCP-1 (10%). By comparison, there was a marked reduction (>40%) in tubular injury in MCP-1–deficient mice (histopathology, apoptosis). MCP-1–deficient mice were not protected from glomerular injury (histopathology, proteinuria, macrophage influx). Macrophage accumulation increased adjacent to tubules in MCP-1–intact mice compared with MCP-1–deficient mice (70%, P < 0.005), indicating that macrophages recruited by MCP-1 induce tubular epithelial cell (TEC) damage. Lipopolysaccharide-activated bone marrow macrophages released molecules that induced TEC death that was not dependent on MCP-1 expression by macrophages or TEC. In conclusion, MCP-1 is predominantly expressed by TEC and not glomeruli, promotes TEC and not glomerular damage, and increases activated macrophages adjacent to TEC that damage TEC during NSN. Therefore, we suggest that blockage of TEC MCP-1 expression is a therapeutic strategy for some forms of kidney disease.

277 citations

Journal ArticleDOI
TL;DR: In this article, a new numerical algorithm was developed to automatically detect TEC bite-outs that are produced by the transit of equatorial plasma bubbles, which was applied to TEC values measured by the Low Latitude Ionospheric Sensor Network (LISN) and by receivers that belong to 3 other networks that exist in South America.
Abstract: [1] This paper presents for the first time regional plots of total electron content (TEC) depletions derived from GPS observations over the South American continent with a coverage of over 45° longitude (i.e., 35°W to 80°W). We introduce a new numerical algorithm that has been developed to automatically detect TEC bite-outs that are produced by the transit of equatorial plasma bubbles. This algorithm was applied to TEC values measured by the Low Latitude Ionospheric Sensor Network (LISN) and by receivers that belong to 3 other networks that exist in South America. The general characteristics of the TEC depletions are provided along with their temporal length, local time distribution and depletion depth. The regional day-to-day and seasonal variability of the TEC depletions are also presented for 2008, a year of low solar activity. The regional day-to-day variability of TEC depletions is highly dynamic, but their seasonal distributions follow the longitudinal characteristics of plasma bubbles presented by other authors. During the equinoxes, TEC depletions are mainly observed on the west coast of South America, and during the December solstice they mostly occur on the east side of the continent. However, in all seasons, we observe days when depletions extend all over the continent. We place these new results in the context of theories of plasma bubble seeding.

273 citations

Journal Article
TL;DR: Data demonstrate that CD40 is expressed and is a functional molecule at the surface of the epithelial cells of the thymus and Triggering of TEC with anti-CD40 mAb in conjunction with IFN-gamma and IL-1 stimulation increased granulocyte-macrophage CSF secretion in a dose-dependent manner.
Abstract: CD40 is a prominent B cell Ag also found on certain epithelial cells and on carcinomas. In this report, we analyzed CD40 distribution in the human thymus. CD40 was not found on the majority of CD45-positive thymocytes, but was present in a CD45-negative stromal cell population. Immunohistology showed CD40 expression on cortical thymic epithelial cells (TEC), medullary TEC, thymic interdigitating cells, and thymic B cells. CD40 was not found on thymocytes, endothelial cells, or on the fibroblasts of the septae. Expression of CD40 was specifically maintained on cultured TEC and not found on cultured thymic fibroblasts. IL-1 alpha, TNF-alpha, IFN-gamma, but not IL-4, significantly up-regulated the membrane expression of CD40 on cultured TEC. The regulation of CD40 was similar to that of ICAM-1, and contrasted with that of MHC class II Ag, which could only be induced by IFN-gamma but not by IL-1, TNF, or IL-4. Northern blot analysis showed the presence of a 1.4-kb mRNA transcript for CD40 in TEC, which was up-regulated by IL-1 and IFN-gamma. Cross-linking of CD40 at the surface of human TEC in the absence of IL-1 stimulation failed to induce cytokine secretion. Triggering of TEC with anti-CD40 mAb in conjunction with IFN-gamma and IL-1 stimulation increased granulocyte-macrophage CSF secretion in a dose-dependent manner. The effect was visible as early as 24 h after triggering, occurred in the absence of cellular proliferation, and was specific for CD40 since triggering of other TEC membrane Ag such as ICAM-1 or MHC class I molecules had no effect to increase cytokine production in TEC. These data demonstrate that CD40 is expressed and is a functional molecule at the surface of the epithelial cells of the thymus.

267 citations

Journal ArticleDOI
TL;DR: In this paper, the authors assess the reliability and validity of a retrospective self-report measure of potential traumatic experiences among psychiatric outpatients, i.e., Traumatic Experiences Checklist (TEC).
Abstract: The objective of the study was to assess the reliability and validity of a retrospective self-report measure of potential traumatic experiences among psychiatric outpatients. The range of evaluated experiences includes emotional neglect and abuse. Participants completed the Traumatic Experiences Checklist (TEC) (N = 153), a self-report trauma questionnaire of known psychometric qualities, i.e. the Stressful Life Experiences Questionnaire (SLESQ), and self-report measures of somatoform dissociation (SDQ-20), psychoform dissociation (DES). A majority (N = 115) completed the TEC twice, and also completed a measure of posttraumatic stress symptoms (PTSD-ss). The TEC's internal consistency and test–retest reliability were good, and the TEC strongly correlated with the SLESQ. Associations between the TEC and the PTSD-ss, DES, and SDQ-20 supported the criterion-related validity of the TEC. The internal consistency, test–retest reliability and criterion-related validity of TEC trauma area presence and severity scores were also satisfactory. Preliminary findings suggest that the psychometric characteristics of the TEC are good. Future study of the TEC should include larger samples of psychiatric patients, as well as non-clinical groups. Copyright © 2002 John Wiley & Sons, Ltd.

264 citations

Journal ArticleDOI
TL;DR: In this paper, a global view of large-scale ionospheric disturbances during the main phase of a major geomagnetic storm is presented, showing that the low-latitude, auroral, and polar latitude regions are coupled by processes that redistribute thermal plasma throughout the system.
Abstract: [1] We present a global view of large-scale ionospheric disturbances during the main phase of a major geomagnetic storm. We find that the low-latitude, auroral, and polar latitude regions are coupled by processes that redistribute thermal plasma throughout the system. For the large geomagnetic storm on 20 November 2003, we examine data from the high-latitude incoherent scatter radars at Millstone Hill, Sondrestrom, and EISCAT Tromso, with SuperDARN HF radar observations of the high-latitude convection pattern and DMSP observations of in situ plasma parameters in the topside ionosphere. We combine these with north polar maps of stormtime plumes of enhanced total electron content (TEC) derived from a network of GPS receivers. The polar tongue of ionization (TOI) is seen to be a continuous stream of dense cold plasma entrained in the global convection pattern. The dayside source of the TOI is the plume of storm enhanced density (SED) transported from low latitudes in the postnoon sector by the subauroral disturbance electric field. Convection carries this material through the dayside cusp and across the polar cap to the nightside where the auroral F region is significantly enhanced by the SED material. The three incoherent scatter radars provided full altitude profiles of plasma density, temperatures, and vertical velocity as the TOI plume crossed their different positions, under the cusp, in the center of the polar cap, and at the midnight oval/polar cap boundary. Greatly elevated F peak density (>1.5E12 m 3 ) and low electron and ion temperatures (2500 K at the F peak altitude) characterize the SED/TOI plasma observed at all points along its high-latitude trajectory. For this event, SED/TOI F region TEC (150–1000 km) was 50 TECu both in the cusp and in the center of the polar cap. Large, upward directed fluxes of O+ (>1.E14 m 2 s 1 ) were observed in the topside ionosphere

259 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023303
2022578
2021284
2020321
2019293
2018272