TEC

About: TEC is a research topic. Over the lifetime, 5119 publications have been published within this topic receiving 84696 citations.

Rat tracheal epithelial cells produce granulocyte/macrophage colony-stimulating factor.

Abstract: It is unknown whether local resident cells of the upper airway are able to regulate the number and function of phagocytic cells by the secretion of cytokines. We undertook to determine if tracheal epithelial cells (TEC) produce the potent cytokine granulocyte/macrophage colony-stimulating factor (GM-CSF) and how TEC-derived GM-CSF might be regulated. Conditioned media (TEC-CM) from 7- to 21-day-old primary cultures of rat TEC contained material with bioactivity similar to GM-CSF. This bioactivity was increased in conditioned medium from lipopolysaccharide (LPS)-treated (1 microgram/ml) TEC. Molecular characterization of bioactivity revealed a molecular weight of 27 to 44 kD by gel-filtration high performance liquid chromatography (HPLC), and elution at 44 to 50% acetonitrile by reverse-phase HPLC, similar to that of authentic GM-CSF. The biologic activity of TEC-CM was completely blocked by a goat polyclonal anti-GM-CSF antibody. With in situ hybridization using a murine GM-CSF cDNA probe, more than 95% of the adherent TEC population expressed GM-CSF transcripts, and the number of transcripts was significantly increased by LPS (1 microgram/ml, 48 h). TEC appear to produce a cytokine that is functionally, biochemically, and antigenically indistinguishable from GM-CSF. The ability of TEC to produce GM-CSF suggests that these cells may play a role in modulating the inflammatory response in the airway.

Ionospheric perturbations observed by the GPS following the December 26th, 2004 Sumatra-Andaman earthquake

Abstract: Using the Total Electron Content (TEC) data recorded by the GPS receiver network, installed under the GPS and Geo Augmented Navigation (GAGAN) program, ionospheric electron content on the day of the great Sumatra-Andaman earthquake of December 26, 2004 was examined. A significant perturbation of 1.5 to 2 TEC units over a smooth variation of TEC in the morning hours was observed within 45 minutes of the quake at stations situated near the east coast of the Indian subcontinent. The disturbance was found to propagate northwestward with its origin situated about 2° northeast of the quake epicenter. Possible coupling mechanism of the crustal movement and the ionosphere are discussed.

Modification of the low-latitude ionosphere before the 26 December 2004 Indonesian earthquake

Abstract: . This paper investigates the features of pre-earthquake ionospheric anomalies in the total electron content (TEC) data obtained on the basis of regular GPS observations from the IGS network. For the analysis of the ionospheric effects of the 26 December 2004 Indonesian earthquake, global TEC maps were used. The possible influence of the earthquake preparation processes on the main low-latitude ionosphere peculiarity – the equatorial anomaly – is discussed. Analysis of the TEC maps has shown that modification of the equatorial anomaly occurred a few days before the earthquake. For 2 days prior to the event, a positive effect was observed in the daytime amplification of the equatorial anomaly. Maximal enhancement in the crests reached 20 TECU (50–60%) relative to the non-disturbed state. In previous days, during the evening and night hours (local time), a specific transformation of the TEC distribution had taken place. This modification took the shape of a double-crest structure with a trough near the epicenter, though usually in this time the restored normal latitudinal distribution with a maximum near the magnetic equator is observed. It is assumed that anomalous electric field generated in the earthquake preparation zone could cause a near-natural "fountain-effect" phenomenon and might be a possible cause of the observed ionospheric anomaly.

Verification of the concept of seismoionospheric coupling under quiet heliogeomagnetic conditions, using the Wenchuan (China) earthquake of May 12, 2008, as an example

Abstract: The variability of the ionosphere during April–May, 2008, has been analyzed in detail in order to reveal anomalous variations related to seismic activity, initiated by the strongest Wenchuan earthquake (M = 7.9) in the Sichuan province on May 12, 2008. Information about the total electron content (TEC) from the network of GPS receivers in the earthquake region, the global IONEX TEC maps, and the reconstructed vertical profiles of electron density according to the data of GPS receivers were used as a data source. The spatial and time localization of the observed anomalies, their morphological features, and the absence of geomagnetic disturbances during the observation period undoubtedly demonstrate that the observed variations were caused by seismic activity.