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TEC

About: TEC is a research topic. Over the lifetime, 5119 publications have been published within this topic receiving 84696 citations.


Papers
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Journal ArticleDOI
TL;DR: In this article, the authors studied ionospheric total electron content (TEC) disturbances associated with tropical cyclones (TCs) in the North-West Pacific Ocean in September-November 2005.

56 citations

Journal ArticleDOI
TL;DR: In this article, the authors presented data from first global positioning system (GPS) measurements of global response of the ionosphere to solar flares of September 23, 1998 and July 29, 1999 and found that fluctuations of total electron content (TEC) obtained by removing the linear trend of TEC with a time window of about 5 min, are coherent for all stations and the line of sight to the GPS satellites on the dayside of the Earth.

56 citations

Journal ArticleDOI
TL;DR: In this paper, the authors proposed a numerical approach based on Akaike's information criterion to detect positive breaks (sudden increase of TEC rate) in the vertical TEC time series without using reference curves.
Abstract: Ionospheric electron enhancement was reported to have occurred ~40 min before the 2011 Tohoku-oki (Mw9.0) earthquake, Japan, by observing total electron content (TEC) with Global Navigation Satellite Systems receivers. Their reality has been repeatedly questioned due mainly to the ambiguity in the derivation of the reference TEC curves from which anomalies are defined. Here we propose a numerical approach, based on Akaike's information criterion, to detect positive breaks (sudden increase of TEC rate) in the vertical TEC time series without using reference curves. We demonstrate that such breaks are detected 25–80 min before the eight recent large earthquakes with moment magnitudes (Mw) of 8.2–9.2. The amounts of precursory rate changes were found to depend upon background TEC as well as Mw. The precursor times also showed Mw dependence, and the precursors of intraplate earthquakes tend to start earlier than interplate earthquakes. We also performed the same analyses during periods without earthquakes to evaluate the usefulness of TEC observations for short-term earthquake prediction.

56 citations

Journal ArticleDOI
TL;DR: Preclinical data demonstrate that inhibition of the cytolytic function of CD8+ T cells and NK cells by PF-06651600 is driven by the inhibition of TEC kinases.
Abstract: PF-06651600 was developed as an irreversible inhibitor of JAK3 with selectivity over the other three JAK isoforms. A high level of selectivity toward JAK3 is achieved by the covalent interaction of PF-06651600 with a unique cysteine residue (Cys-909) in the catalytic domain of JAK3, which is replaced by a serine residue in the other JAK isoforms. Importantly, 10 other kinases in the kinome have a cysteine at the equivalent position of Cys-909 in JAK3. Five of those kinases belong to the TEC kinase family including BTK, BMX, ITK, RLK, and TEC and are also inhibited by PF-06651600. Preclinical data demonstrate that inhibition of the cytolytic function of CD8+ T cells and NK cells by PF-06651600 is driven by the inhibition of TEC kinases. On the basis of the underlying pathophysiology of inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, alopecia areata, and vitiligo, the dual activity of PF-06651600 toward JAK3 and the TEC kinase family may provide a beneficial inhibitory profile for therapeutic intervention.

56 citations

Journal ArticleDOI
TL;DR: In this article, dedicated Raman scattering experiments were conducted for graphene monolayers deposited on silicon nitride substrates and over a broad temperature range extending over 150--800 K. The relation between those measurements for the $G$ band and the graphene TEC, which involves correcting the measured signal from the mismatch contribution of the substrate, was analyzed based on different theoretical candidates for $\ensuremath{\alpha}(T)$.
Abstract: Measurements and calculations have shown significant disagreement regarding the sign and temperature variations of the thermal expansion coefficient (TEC) of graphene $\ensuremath{\alpha}(T)$. Here we report dedicated Raman scattering experiments conducted for graphene monolayers deposited on silicon nitride substrates and over a broad temperature range extending over 150--800 K. The relation between those measurements for the $G$ band and the graphene TEC, which involves correcting the measured signal from the mismatch contribution of the substrate, is analyzed based on different theoretical candidates for $\ensuremath{\alpha}(T)$. Contrary to calculations in the quasiharmonic approximation, a many-body potential reparametrized for graphene correctly reproduces experimental data, suggesting that the TEC is more likely to be positive above room temperature.

56 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023303
2022578
2021284
2020321
2019293
2018272