Showing papers on "Terpene published in 1995"
Journal Article•
TL;DR: The effects of linalool revealed by this evaluation are useful to understand the traditional medical use of several plant species in different continents and point to the validity of exploring terpenes as sources of new anticonvulsant agents.
93 citations
TL;DR: The unsubstituted monocyclic monoterpene limonene has been shown to prevent carcinogen‐induced mammary cancer at both the initiation and the promotion/progression stages.
Abstract: Monoterpenes, found in a wide variety of plants, are a major component of plant essential oils. The unsubstituted monocyclic monoterpene limonene has been shown to prevent carcinogen-induced mammary cancer at both the initiation and the promotion/progression stages. This terpene also causes the complete regression of the majority of advanced rat mammary cancer when added to the diet. Modification of limonene by hydroxylation at various positions increases both its chemopreventive and therapeutic efficacy. For example, the naturally occurring hydroxylated limonene analog perillyl alcohol is 5-10 times more potent than limonene and has a similar therapeutic index. Several cellular, metabolic and molecular activities are associated with terpene exposure. These include induction of phase I and II hepatic detoxification enzymes, selective inhibition of protein isoprenylation, inhibition of CoQ synthesis, and induction of the mannose 6-phosphate/IGFII receptor and TGF beta. Due to the therapeutic efficacy of monoterpenes in experimental model systems, clinical evaluation of this class of compounds has begun in advanced cancer patients. A Phase I trial of limonene is in progress in the UK. Efforts in the US will target perillyl alcohol for Phase I testing. Pre-IND toxicology is currently being completed. Phase I trails are anticipated to begin in the Spring of 1995. We feel that the results of these therapeutic trials, if positive, will facilitate the development of current terpenes and more potent analogs for future chemoprevention trials.
86 citations
TL;DR: In this article, seasonal variations of the leaf oil contents and the amounts of terpene emission of Cryptomeria japonica, Chamaecyparis obtusa, Abies sachalinensis, Thuja occidentalis,Thuja standishii, Cupressus sempervirens and Cinnamomum japonicum were studied.
51 citations
TL;DR: The intracelullar accumulation of intermediate terpenic precursors for squalene may favor cyclizations, isomerizations, and enzymatic conversions among terpenes and their excretion, increasing the contents of these compounds in the vines.
Abstract: Intracellular changes in terpenic compounds during alcoholic fermentations of musts from grapes of cv. Pedro Ximenez carried out by three Saccharomyces cerevisiae races, as well as during veil formation, were studied. The intracellular accumulation of geraniol, linalool, α-terpineol, (E)nerolidol, and (Z)-nerolidol throughout the period studied may be the result of inhibited sterol biosynthesis from squalene by anaerobic conditions. This intracelullar accumulation of intermediate terpenic precursors for squalene may favor cyclizations, isomerizations, and enzymatic conversions among terpenes and their excretion, increasing the contents of these compounds in the vines
32 citations
TL;DR: Five lipases were screened for their ability to synthesize terpene esters by transesterification and Lipase AY from Candida rugosa gave the best overall yield.
Abstract: Five lipases were screened for their ability to synthesize terpene esters by transesterification. The nature of terpene alcohol and enzyme, as well as the chain length of the acyl donor used affected the product yields. Lipase AY from Candida rugosa gave the best overall yield (96.2%). Geraniol and tributyrin were also found to be the best reactants.
27 citations
Patent•
27 Jun 1995TL;DR: A disinfectant concentrate contains: a) known disinfectants; b) conventional adjuvants; c) water; and d) 0.1-50% terpene(s).
Abstract: A disinfectant concentrate contains: a) known disinfectants; b) conventional adjuvants; c) water; and d) 0.1-50 wt.% terpene(s). The concentrate conveniently has a terpene concn. of 1-15 wt.%, pref. 1.5-10 wt.%, esp. 2-8 wt.%. Pref. disinfectants are aldehydes, quat ammonium cpds., amine (salts), amphoteric surfactants and glycols or glycol ethers. The terpenes (d) are conveniently monoterpenes, sequiterpenes, diterpenes, sesterpenes, triterpenes and/or tetraterpenes. Terpene mixts., known as "orange terpene" and "lemon terpene", contg. the natural terpenes, e.g. citronellol, geraniol and neral, found in oranges and lemons are esp. suitable.
26 citations
Patent•
26 Jul 1995TL;DR: In this article, a composition which comprises a major amount of an organic polysulfide and an odor masking amount of a compound selected from the group consisting of wintergreen, cinnamons, vanillins, terpenes, sesquiterpenes and combinations of any two or more thereof is provided.
Abstract: A composition which comprises a major amount of an organic polysulfide and an odor-masking amount of an odor-masking compound selected from the group consisting of wintergreen, cinnamons, vanillins, terpenes, sesquiterpenes, and combinations of any two or more thereof is provided wherein the composition has a more pleasant odor than the organic polysulfide
24 citations
TL;DR: All four terpene alcohols and the mixture were toxic to O. surinamensis, with α-terpineol proving most toxic and linalool the least toxic.
20 citations
12 citations
Journal Article•
6 citations
Patent•
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21 Feb 1995
TL;DR: In this paper, the authors proposed to obtain feed for livestock effective in preventing and treating coccidiosis of livestock, especially domestic fowl by including terpenes or essential oil containing the terpene into feed.
Abstract: PURPOSE:To obtain feed for livestock effective in preventing and treating coccidiosis of livestock, especially domestic fowl by including terpenes or essential oil containing the terpene into feed. CONSTITUTION:This feed for livestock contains terpenes such as eucalyptus oil, perillaldehyde, citral, borneol and clove oil and/or essential oil containing these terpenes. Final concentration of terpenes or essential oil containing these terpenes in feed for live stock is about 100-10000ppm, preferably about 500-5000ppm.
TL;DR: In this article, the authors synthesizeorosadienone (9) from 2,6-dimethylcyclohexanone via indenone 1 and dienone 4 using the α,β,γ,δ-dienone system.
Abstract: (±)-Porosadienone (9) is easily synthesized by starting from (±)-2,6-dimethylcyclohexanone via indenone 1 and dienone 4. All compounds (rac-4-6 and rac-9) with the α,β,γ,δ-dienone system are very prone to air oxidation forming the corresponding mono epoxides rac-7, rac-8, rac-10, and rac-11.
TL;DR: In this article, the bromo-ether cyclization reactions of laurediols are also deseribed, and molecular modeling studies on the cyclization reaction of bromoencoderoxidase for (3 E,6 S,7 S )-lauredol with H 2 O 2 and NaBr are discussed.
Abstract: The biosynthetic reaction of (3 E ,6 S ,7 S )-laurediol with H 2 O 2 and NaBr by lactoperoxidase afforded ( E )-prelaureation. The molecular modeling studies on the bromo-ether cyclization reactions of laurediols are also deseribed.
TL;DR: The chemical composition of the essential oils of the leaves and stem bark of Canella winterana (L.) Gaertn was investigated by GC and GC/MS as discussed by the authors, and 27 components were identified: mono- and sesquiterpene hydrocarbons (34.9%), oxygenated terpenes (58.3%), and phenolic components (6.8%).
Abstract: The chemical composition of the essential oils of the leaves and stem bark of Canella winterana (L.) Gaertn. (Canellaceae), was investigated by GC and GC/MS. In die oil of the stem bark, 27 components were identified: mono- and sesquiterpene hydrocarbons (34.9%), oxygenated terpenes (58.3%), and phenolic components (6.8%). The main constituents of the oil were 1,8-cineole (37.0%), terpinen-4-ol (10.7%), α-terpinyl acetate (9.2%) and α-terpineol (6.8%). The leaf oil was found to be rich in myrcene (68.0%).
Patent•
06 Jan 1995
TL;DR: In this article, the authors presented a subject composition containing a terpene hydrocarbon, a metal sequestering agent (e.g. sodium tripolyphosphate), a specific component and water at respective specific ratios.
Abstract: PURPOSE:To obtain the subject composition containing a terpene hydrocarbon, a terpene alcohol, a specific component and water at respective specific ratios and exhibiting strong detergent powder on the stain of a fiber dyeing machine such as wince. CONSTITUTION:This composition contains (A) 1-40wt.% of a terpene hydrocarbon (alpha-limonene) and/or a terpene alcohol (e.g. linalool), at least one component selected from (B) 1-30wt.% of a nonionic surfactant (e.g. alkyl polyoxyalkylene ether) and/or an anionic surfactant (e.g. alkylaryl sulfonic acid salt), (C) 5-40wt.% of a compound of the formula (R is ethylene or propylene; l is 2-100; m is 0 or 1-4; n is 2 or 3) and (D) 1-15wt.% of a metal sequestering agent (e.g. sodium tripolyphosphate) and (E) the remaining part of water.
Patent•
14 Jun 1995
TL;DR: The microporous catalysts used in the prepn. of p-Cymol (I) by reacting turpentine, or the terpene(s) present in turpentINE, are molecular sieves doped with noble and/or lanthanide metals and are in neutral form or converted to a slightly acidic form by ion exchange up to a pH of > 4.5 as mentioned in this paper.
Abstract: The microporous catalysts used in the prepn. of p-Cymol (I) by reacting turpentine, or the terpene(s) present in turpentine, are molecular sieves doped with noble and/or lanthanide metals and are in neutral form or converted to a slightly acidic form by ion exchange up to a pH of > 4.5.
TL;DR: In this paper, a sesquiterpene was isolated from the latex of Artemisia subdigitata and its structure was established on the basis of spectral methods (MS, IR, 1H NMR, (13)C NMR and DEPT).
Abstract: A new sesquiterpene was isolated from the latex of Artemisia subdigitata. On the basis of spectral methods (MS, IR, 1H NMR, (13)C NMR and DEPT, 1H-1H COSY, 1H-(13)C COSY and 1H-(13)C COLOC), its structure was established.
TL;DR: In this paper, the resolution of racemic cis and trans-linalool oxide-pyranoid via esterification with malonic acid by Glomerella cingulata is described.
Abstract: Resolution of racemic cis and trans -linalool oxide-pyranoid via esterification with malonic acid by Glomerella cingulata , is described. The enantiomerically pure alcohols and malonic esters can be obtained.
TL;DR: In this paper, a protected C-1 side chain precursor of the squalestatins and zaragozic acid A has been achieved in 9 steps from 1,4-butanediol.
Abstract: A synthesis of a protected C-1 side chain precursor ( 2 ) of the anti-cholesteremic agents the squalestatins and zaragozic acid A has been achieved in 9 steps from 1,4-butanediol. The key transformations involve a one pot oxidation/α-methylenation sequence to provide the α,β-unsaturated aldehyde 4 and subsequent asymmetric aldol reaction to introduce the C-4′ and C-5′ stereocentres.
TL;DR: In this paper, the synthesis of the unusual sesquiterpene (±)-myltayl-4(12)-ene from cyclogeraniol and the single-crystal X-ray structure of the 4-nitrobenzoate 12 of the noralcohol was described.
Abstract: The total synthesis of the unusual sesquiterpene (±)-myltayl-4(12)-ene 3 starting from the readily available cyclogeraniol 5 and the single-crystal X-ray structure of the 4-nitrobenzoate 12 of the noralcohol 11 are described.