Topic
Terpene
About: Terpene is a research topic. Over the lifetime, 2208 publications have been published within this topic receiving 51480 citations. The topic is also known as: terpenes.
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TL;DR: This study aimed to determine the frequency and characteristics of allergic reactions to selected oxidized fragrance terpenes other than limonene, and found that 58% had fragrance‐related contact allergy and/or a positive history for adverse reaction to fragrances.
Abstract: Terpenes are widely used fragrance compounds in fine fragrances, but also in domestic and occupational products. Terpenes oxidize easily due to autoxidation on air exposure. Previous studies have shown that limonene, linalool and caryophyllene are not allergenic themselves but readily form allergenic products on air-exposure. This study aimed to determine the frequency and characteristics of allergic reactions to selected oxidized fragrance terpenes other than limonene. In total 1511 consecutive dermatitis patients in 6 European dermatology centres were patch tested with oxidized fragrance terpenes and some oxidation fractions and compounds. Oxidized linalool and its hydroperoxide fraction were found to be common contact allergens. Of the patients tested, 1.3% showed a positive reaction to oxidized linalool and 1.1% to the hydroperoxide fraction. About 0.5% of the patients reacted to oxidized caryophyllene whereas 1 patient reacted to oxidized myrcene. Of the patients reacting to the oxidized terpenes, 58% had fragrance-related contact allergy and/or a positive history for adverse reaction to fragrances. Autoxidation of fragrance terpenes contributes greatly to fragrance allergy, which emphasizes the need of testing with compounds that patients are actually exposed to and not only with the ingredients originally applied in commercial formulations.
162 citations
161 citations
Book•
01 Jan 2013
TL;DR: Part I Alkaloids: General Biology and Biotechnology, Part II AlkAloids: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution., Part VII Phenolics: Methods of Analysis, Biological Activity and Bioavailability as discussed by the authors.
Abstract: Part I Alkaloids: General Biology and Biotechnology.- Part II Alkaloids: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part III Alkaloids: Methods of Analysis.- Part IV Alkaloids: Pharmacology.- Part V Phenolics: General Biology and Biotechnology.- Part VI Phenolics: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part VII Phenolics: Methods of Analysis.- Part VIII Phenolics: Biological Activity and Bioavailability.- Part IX Phenolics: Nutraceuticals and Functional Foods.- Part X Terpenes: General Biology and Biotechnology.- Part XI Terpenes: Classes - Occurrence, Biosynthesis, Structure and Chemistry, Distribution.- Part XII Terpenes: Methods of Analysis.- Part XIII Terpenes: Pharmacology and Bioavailability.- Part XIV Terpenes: Parapharmaceutical Uses.
159 citations
TL;DR: The respective alcoholic terpenes carvacrol, linalool, and alpha-terpineol were used at 5% w/v in propylene glycol to increase the in vitro permeation of haloperidol through human skin, and the possible enhancement mechanism was elucidated with HP-stratum corneum (SC) binding studies, Fourier transform infrared spectroscopy, and differential scanning calorimetry.
159 citations
TL;DR: In this article, a two-year study was carried out to determine the evolution of free and bound aromatic compounds of Muscat grape (sp. Vitis vinifera cv. Muscat Hamburg) during ripening.
158 citations