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Terpene

About: Terpene is a research topic. Over the lifetime, 2208 publications have been published within this topic receiving 51480 citations. The topic is also known as: terpenes.


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Journal ArticleDOI
TL;DR: This is the first report on the biotransformation of these terpenes by Colletotrichum spp.
Abstract: To investigate the biocatalytic potential of Colletotrichum acutatum and Colletotrichum nymphaeae for monoterpene biotransformation. C. acutatum and C. nymphaeae used limonene, α-pinene, β-pinene, farnesene, citronellol, linalool, geraniol, perillyl alcohol, and carveol as sole carbon and energy sources. Both species biotransformed limonene and linalool, accumulating limonene-1,2-diol and linalool oxides, respectively. α-Pinene was only biotransformed by C. nymphaeae producing campholenic aldehyde, pinanone and verbenone. The biotransformation of limonene by C. nymphaeae yielded 3.34–4.01 g limonene-1,2-diol l−1, depending on the substrate (R-(+)-limonene, S-(−)-limonene or citrus terpene (an agro-industrial by-product). This is among the highest concentrations already reported for this product. This is the first report on the biotransformation of these terpenes by Colletotrichum spp. and the biotransformation of limonene to limonene-1,2-diol possibly involves enzymes similar to those found in Grosmannia clavigera.

18 citations

Journal ArticleDOI
TL;DR: In this review, six distinct subsets of characterized prenyltransferases are structurally and mechanistically classified, including (1) head‐to‐tail preny synthase, (2) head-to‐head pre-nyl synthases, (3) head•to‐middle pre-NLS, (4) terpenoid cycl enzyme, (5) aromatic preNyltransferase, and (6) proteinPrenylation.
Abstract: Isoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five-carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and include dolichols, steroid hormones, carotenoids, retinoids, aromatic metabolites, the isoprenoid side-chain of ubiquinone, and isoprenoid attached signaling proteins. Productions of isoprenoids are catalyzed by a group of enzymes known as prenyltransferases, such as farnesyltransferases, geranylgeranyltransferases, terpenoid cyclase, squalene synthase, aromatic prenyltransferase, and cis- and trans-prenyltransferases. Because these enzymes are key in cellular processes and metabolic pathways, they are expected to be potential targets in new drug discovery. In this review, six distinct subsets of characterized prenyltransferases are structurally and mechanistically classified, including (1) head-to-tail prenyl synthase, (2) head-to-head prenyl synthase, (3) head-to-middle prenyl synthase, (4) terpenoid cyclase, (5) aromatic prenyltransferase, and (6) protein prenylation. Inhibitors of those enzymes for potential therapies against several diseases are discussed. Lastly, recent results on the structures of integral membrane enzyme, undecaprenyl pyrophosphate phosphatase, are also discussed.

18 citations

Journal ArticleDOI
TL;DR: The biosynthetic pathway of some terpenic hydrocarbons present in the larval osmeterial secretions of Luehdorfia and Papilio species was examined by in vivo experiments, using 13C-labelled acetic acid, substantiating de novo biosynthesis of terpenes from acetate precursors by these larvae.

17 citations

DOI
23 Jan 2015
TL;DR: Terpenes are polymers of isoprenoid units as discussed by the authors, which are five carbon compounds and are favorite nature's building blocks and emit fragrances which allow them to be used as insect repellants, aids in pollination, perfume preparation, cosmetics and also has many medicinal values if used in required quantities.
Abstract: Terpenes are polymers of isoprenoid units. These isoprenoid units are five carbon compounds and are favorite nature’s building blocks. In terpenes these isoprenoids are arranged in a regular head to tail fashion. The side chains of Vitamin A, E, K, squalene (unsaturated hydrocarbon found in shark, humans) are all constituents of terpenes. Terpenes emit fragrances which allow them to be used as insect repellants, aids in pollination, perfume preparation, cosmetics and also has many medicinal values if used in required quantities. Adverse usage of terpenes has toxic effects like seizures, CNS depression, nausea vomiting etc.

17 citations

Journal ArticleDOI
TL;DR: In this article, the hydride shifts accompanying 2,3-epoxysqualene cyclisation to lanosterol in yeast and to β-amyrin in peas have been checked using 2, 3-epoxy[11, 14-3H2]squalene.
Abstract: The hydride shifts accompanying 2,3-epoxysqualene cyclisation to lanosterol in yeast and to β-amyrin in peas have been checked using 2,3-epoxy[11,14-3H2]squalene. The results support the Ruzicka–Eschenmoser hypothesis and not a plausible alternative which was considered. The synthesis of 2,3-epoxy[11,14-3H2]squalene by two routes is described.

17 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023400
2022834
202190
202093
201970
201895