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Terpene

About: Terpene is a research topic. Over the lifetime, 2208 publications have been published within this topic receiving 51480 citations. The topic is also known as: terpenes.


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Journal ArticleDOI
TL;DR: Among the investigated terpenes, carvone (6), pulegone (8) and y-terpinene (7) can be recognized as compounds with most promising activities in the development of multi-target directed ligands.
Abstract: Abstract Alzheimer’s disease (AD) is by far the most prevalent of all known forms of dementia. Despite wide-spread research, the main causes of emergence and development of AD have not been fully recognized. Natural, low-molecular, lipophilic terpenoids constitute an interesting group of secondary plant metabolites, that exert biological activities of possible use in the prevention and treatment of AD. In order to identify secondary metabolites possessing both antioxidant activity and the potential to increase the level of acetylcholine, selected terpenoids have been screened for possible acetylcholinesterase inhibitory activity by use of two methods, namely Marston (chromatographic assay) and Ellman (spectrophotometric assay). In order to describe the interaction between terpenes and AChE active gorge, molecular docking simulations were performed. Additionally, all analyzed terpenes were also evaluated for their cytotoxic properties against two normal cell lines using MTT assay. The obtained results show that: carvone (6), pulegone (8) and γ-terpinene (7) possess desirable AChE inhibitory activity. MTT assay revealed low or lack of cytotoxicity of these metabolites. Thus, among the investigated terpenes, carvone (6), pulegone (8) and y-terpinene (7) can be recognized as compounds with most promising activities in the development of multi-target directed ligands.

30 citations

Journal ArticleDOI
TL;DR: GUG-βCD was superior to G2- βCD, especially in the solid state, and this result may have been caused by the difference in structure of side chain, namely the hydroxymethyl group in G2 -βCD and the carboxyl group inG2-β CD.
Abstract: In order to investigate the application potential of branched CDs, the solubilizing ability and the stabilizing ability of G2-βCD and GUG-βCD were investigated by using twelve terpenes (d-limonene, myrcene, terpinolene, geraniol, l-menthol, nerol, α-terpineol, citral, d-citronellal, l-perillaldehyde, (R)-l-carvone, and menthone) as guest compounds. G2-βCD and GUG-βCD showed more solubilizing ability for these twelve terpenes than βCD, and the ability of GUG-βCD was almost the same as that of G2-βCD. The stabilizing ability of terpene-GUG-βCD complexes was different from that of G2-βCD. GUG-βCD was superior to G2-βCD, especially in the solid state. This result may have been caused by the difference in structure of side chain, namely the hydroxymethyl group in G2-βCD and the carboxyl group in GUG-βCD.

30 citations

Journal ArticleDOI
TL;DR: The biosynthetic pathways of terpenoids produced by Streptomyces and their related novel enzymes are described and can be further diversified by subsequent modification reactions, such as hydroxylation and glycosylation.
Abstract: Terpenoids are a large and highly diverse group of natural products. All terpenoids are biosynthesized from isoprenyl diphosphate formed by the consecutive condensation of the five-carbon monomer isopentenyl diphosphate (IPP) to its isomer dimethylallyl diphosphate (DMAPP). Two distinct biosynthetic pathways produce the essential primary metabolites IPP and DMAPP: the 2-C-methylerythritol 4-phosphate pathway and the mevalonate pathway. The isoprenyl substrates can be cyclized by terpene cyclase into single-ring or multi-ring products, which can be further diversified by subsequent modification reactions, such as hydroxylation and glycosylation. This review article describes the biosynthetic pathways of terpenoids produced by Streptomyces and their related novel enzymes.

30 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023400
2022834
202190
202093
201970
201895