Topic
Testosterone
About: Testosterone is a research topic. Over the lifetime, 23258 publications have been published within this topic receiving 808079 citations. The topic is also known as: 4-androsten-17beta-ol-3-one & 4-Androsten-3-one-17b-ol.
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TL;DR: Increased endothelium-dependent dilatation was significantly associated with low serum testosterone levels but not with cholesterol levels or with a past history of malignancy, consistent with a deleterious effect of physiologic levels of male sex steroids on the arterial wall.
Abstract: Male gender is an independent risk factor for coronary artery disease, and androgen administration has been associated with increased atherosclerosis in experimental animals. Since endothelial dysfunction is an important event in the atherogenic process, we hypothesized that androgen deprivation in adult men might be associated with enhanced arterial endothelial function. Using external vascular ultrasound, brachial artery diameter was measured at rest, after flow increase (causing endothelium-dependent dilatation) and after nitroglycerin (an endothelium-independent dilator). We studied 30 adult males aged 40 to 70 years: 10 had had bilateral orchidectomy and/or maximal androgen blockade for > or = 6 months for treatment of prostate cancer, and all were in complete remission (group 1). Ten healthy controls (group 2) and 10 controls who had remission from nonprostate cancers (group 3) were matched for age and smoking history. Testosterone levels were lower in men in group 1 versus groups 2 or 3 (0.8 +/- 0.1 versus 19.2 +/- 8.4 or 16.1 +/- 4.9 nmol/L, P .25). The withdrawal of male sex hormones may be associated with enhanced endothelial function in adult men. This is consistent with a deleterious effect of physiologic levels of male sex steroids on the arterial wall.
168 citations
TL;DR: It is concluded that estradiol in the presence or absence of testosterone decreases total accumulation of vascular connective tissue and alters the proportions of collagen and elastin so that the vessel is more distensible in the male rat.
Abstract: Aortic collagen and elastin were quantitated in three groups of castrated and two groups of noncastrated male rats treated by intramuscular injection for 3 wk with oil, testosterone, or estradiol. ...
168 citations
TL;DR: FGF-10 appears to act as a growth factor which is required for development of the prostate and several other accessory sex organs, including the seminal vesicle, bulbourethral gland, and caudal ductus deferens.
168 citations
TL;DR: Radioimmunoassay of T and 5 alpha-DHT showed that T-males and T-females have similar plasma levels of androgens, and no striking differences were observed in the way testosterone is metabolized by the pituitary gland and central nervous tissues of males and females.
168 citations
TL;DR: The results indicate that growth hormone acts as a repressive factor for the constitutive and inducible levels of P-450b and P- 450e in a manner different from the regulation ofP-450-male and P -450-female.
168 citations