Topic
Tetrahydrofuran
About: Tetrahydrofuran is a research topic. Over the lifetime, 11778 publications have been published within this topic receiving 158241 citations. The topic is also known as: diethylene oxide & 1,4-epoxybutane.
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TL;DR: In this article, the authors showed that for open-chain unsaturated alcohols with the general formula R1R2C=CH(CH2)nCR 1R2OH (whereR1,R2=H or CH3, andn=1-3) the regioselectivity for such reaction is 100% when R1 or R2=CH3, among the diasteroisomeric productstranspredominates overcis.
42 citations
TL;DR: The first highly enantioselective syntheses of tetra-substituted tetrahydrofuran lignan, (-)- and (+)-virgatusin, were achieved.
Abstract: The first highly enantioselective syntheses of tetra-substituted tetrahydrofuran lignan, (−)- and (+)-virgatusin, were achieved. Hemiacetal 15 was stereoselectively obtained from Evans's syn-aldol product 8 as a single isomer. This hemiacetal 15 was converted to (−)-virgatusin via hydrogenolysis. (+)-Virgatusin was also synthesized through the same process. The enantiomeric excess of the both enantiomers was determined as more than 99% ee.
42 citations
Patent•
09 Nov 1998
TL;DR: In this article, a biocompatible polymeric coating material is selected from the group consisting of linear, dendrimeric and branched polymers which contain primary, secondary, tertiary or quaternary amine groups with hydrophobic side chains and which polymers are insoluble, or only slightly soluble, in aqueous solution at a pH range between 3 and 11 and soluble in at least one organic solvent.
Abstract: The invention provides a biocompatible polymeric coating material, wherein the polymeric material is selected from the group consisting of linear, dendrimeric and branched polymers which contain primary, secondary, tertiary or quaternary amine groups with hydrophobic side chains and which polymers are insoluble, or only slightly soluble, in aqueous solution at a pH range between 3 and 11 and soluble in at least one organic solvent selected from the group consisting of alcohols, acetone, methyl ethyl ketone, tetrahydrofuran, dioxane, chloroform, dichloromethane, hexanes and mixtures thereof.
42 citations
TL;DR: In this article, two chiral derivatization reagents, D- and L-1-aminoethyl-4-dimethyl-aminonaphthalene, were synthesized from 1-dimethylaminonaphthene.
42 citations
TL;DR: In this article, a dialkylsulfonio-methylation has been observed on the treatment of the 7,8-C2B9H12(-) ion with formaldehyde and dialkyl sulfides in aqueous acidic medium.
Abstract: Dialkylsulfonio-methylation has been observed on the treatment of the 7,8-C2B9H12(-) ion with formaldehyde and dialkyl sulfides in aqueous acidic medium. Four zwitterions of the type 9-R2S-CH2-7,8-C2B9H11 were formed with dimethyl and diethyl sulfide, tetrahydrothiophene and thioxane. In contrast, dialkyl ethers (diethyl ether, tetrahydrofuran, dioxane) afforded low amounts of the 10-R2O-7,8-C2B9H11 zwitterions, with the carborane 4,5- C2B7H13 being the principal product. Using acetaldehyde instead of formaldehyde, moderate yields of the 10-R2O- and high yields of the 10-R2S-7,8-C2B9H11 derivatives were obtained. With tertiary amines, only corresponding ammonium salts precipitated. Possible reaction pathways for these transformations are discussed and compared with the specific degradation of the 7,8-C2B9H12(-) ion to the arachno-4,5- C2B7H13 carborane.
42 citations