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Tetrahydrofuran

About: Tetrahydrofuran is a research topic. Over the lifetime, 11778 publications have been published within this topic receiving 158241 citations. The topic is also known as: diethylene oxide & 1,4-epoxybutane.


Papers
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Journal ArticleDOI
TL;DR: In this article, β-Unsaturated nitroalkenes are readily reduced to the corresponding oximes in good yields using ammonium formate in the presence of palladium.

80 citations

Journal ArticleDOI
TL;DR: In this article, a mixture of tetrahydrofuran (THF) and hydrogen/Tetrahedrofurant mixed hydrate formation studies were conducted in a stirred tank reactor.

80 citations

Journal ArticleDOI
TL;DR: The salt-free trialkyl-alkylidenephosphoranes R2RR as discussed by the authors 2a-2o (R, R' = alkyl; R”= H, alkyL; R´ = H, Alkyl, 2-Propenyl) are prepared by treating the corresponding phosphonium chlorides or bromides in boiling tetrahydrofuran.

79 citations

Journal ArticleDOI
TL;DR: In this article, a new method for the synthesis of tetrahydrofuran derivatives from vinylic oxiranes and activated olefins was proposed, which is based on the use of Michael acceptors having sterically less bulky electron-withdrawing groups.
Abstract: The reaction of certain activated olefins (Michael acceptors) 5 with vinylic oxiranes 1 in the presence of catalytic amounts of Pd(PPh3)4 (5 mol %) in THF at 40 °C gave the corresponding [3 + 2] cycloaddition products 6. In all cases the reactions proceeded in regioselective manner, affording the corresponding polysubstituted tetrahydrofuran derivatives. The nature of electron-withdrawing group in activated olefins affected significantly the reactivity of substrates. Michael acceptors having sterically less bulky electron-withdrawing groups were essential for the cycloaddition reaction, and the presence of two electron-withdrawing groups at the α-position was needed. Accordingly, activated olefins having (CN, CN), (CN, CO2Et), (CN, SO2Ph), (Meldrum's type), and (SO2Ph, SO2Ph) could be used as a Michael acceptor. The present reaction provides a new method for the synthesis of tetrahydrofuran derivatives from vinylic oxiranes and Michael acceptors.

79 citations

Journal ArticleDOI
TL;DR: A hydrogen abstraction and oxygen rebound mechanism that oxidizes ethers to hemiacetals, which subsequently hydrolyze may have a role in the biodegradation of natural and anthropogenic low molecular weight ethers in soils and plant litter.

79 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023194
2022382
2021124
2020154
2019193
2018218