Tetraparesis

About: Tetraparesis is a research topic. Over the lifetime, 247 publications have been published within this topic receiving 1875 citations.

Handbook of Veterinary Neurology

Abstract: Part I: Fundamentals 1. Neurologic History, Neuroanatomy, and Neurologic Examination 2. Localization of Lesions in the Nervous System 3. Disorders of Micturition 4. Confirming a Diagnosis Part II: Clinical Problems: Signs and Symptoms 5. Paresis of One Limb 6. Pelvic Limb Paresis, Paralysis, or Ataxia 7. Tetraparesis, Hemiparesis, and Ataxia 8. Ataxia of the Head and Limbs 9. Disorders of the Face, Tongue, Esophagus, Larynx, and Hearing 10. Disorders of Involuntary Movement 11. Blindness, Anisocoria, and Abnormal Eye Movements 12. Stupor or Coma 13. Seizures, Narcolepsy, and Cataplexy 14. Pain 15. Systemic or Multifocal Signs Appendix: Breed-Specific Neuromuscular Diseases in Domestic Animals

Treatment of adductor spasticity with BTX-A in children with CP: a randomized, double-blind, placebo-controlled study.

Abstract: Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee–knee distance ‘fast catch’, p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

A prospective survey of the causes of non-traumatic spastic paraparesis and tetraparesis in 585 patients

Abstract: Objective: To ascertain the relative frequencies of the causes of non-traumatic paraparesis and tetraparesis in adults. Design: Survey of patients enrolled prospectively over a 3 year period between 1986 and 1989 and review of their case notes 1 year after enrollment ceased (mean duration of follow up 30 months). Setting: Regional neurosciences centre in the UK serving over three million people in Merseyside and North Wales. Patients: Experienced clinicians from the centre saw most patients in the region with non-traumatic spastic paraparesis or tetraparesis. Primary investigation of patients was by myelography, for which patients were admitted to the centre. 585 consecutive patients with spastic paraparesis or tetraparesis were identified by daily screening of all 2104 patients undergoing myelography or radiculography during the 3 year period, ie selection by the intention to investigate them for myelopathy. Exclusions: age under 15 years, previous myelography for myelopathy. Interventions: None. Main outcome measures: Numbers and proportions of patients with each condition or category of disease. Results: Commonest diagnoses were cervical spondylotic myelopathy (23.6%), extrinsic neoplastic or developmental tumour (16.4%), multiple sclerosis (9.1% rising to 17.8% after MRI of a selected group), and motor neurone disease (4.1%). Diagnosis was uncertain in 27.4%, falling to 18.6% after MRI. Conclusions: This survey shows the pattern of diseases producing non-traumatic myelopathy in the Mersey Region and in North Wales. Changing patterns of referral, investigation in peripheral hospitals and by non neurologically trained practitioners, and increasing use of outpatient MRI for primary investigation may make comparable surveys impossible in the future.

Clinical evaluation of three surgical methods for treatment of caudal cervical spondylomyelopathy of dogs.

Abstract: Sixty-four dogs with caudal cervical spondylomyelopathy (CCSM) caused by chronic degenerative disc disease were treated with ventral decompression (n = 20), linear traction and interbody screw stabilization (n = 7), or linear traction and plastic plate stabilization (n = 37). Interbody screw stabilization was ineffective in treating CCSM because of an unacceptably high rate of implant failures. Ventral decompression or linear traction and plastic plate stabilization were effective in the treatment of most patients with mild to moderate neurologic deficits (neck pain, paraparesis, or ambulatory tetraparesis). Although these techniques were also used successfully in some patients with severe neurologic deficits (weakly ambulatory tetraparesis or nonambulatory tetraparesis), variable success rates and prolonged postoperative recovery periods were noted.

The central nervous system phenotype of X-linked Charcot-Marie-Tooth disease: a transient disorder of children and young adults.

Abstract: We describe 2 patients with X-linked Charcot-Marie-Tooth disease, type 1 (CMTX1) disease and central nervous system manifestations and review 19 cases from the literature. Our first case had not been previously diagnosed with Charcot-Marie-Tooth disease, and the second case, although known to have Charcot-Marie-Tooth disease, was suspected of having CMTX1 after presentation with central nervous system manifestations. The most common central nervous system manifestations were transient and included dysarthria, ataxia, hemiparesis, and tetraparesis resembling periodic paralysis. Of the 21 patients, 19 presented at 21 years of age or younger, implicating CMTX1 with transient central nervous system manifestations as a disorder that predominantly affects children and adolescents. CMTX1 should be included in the differential diagnosis of patients who present with transient central nervous system phenomena, including stroke-like episodes, tetraparesis suggestive of periodic paralysis, dysarthria, ataxia, or combinations of these deficits. Reversible, bilateral, nonenhancing white matter lesions and restricted diffusion on magnetic resonance imaging are characteristic features of the central nervous system phenotype of CMTX1.