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Showing papers on "Theobromine published in 1971"



Journal ArticleDOI
TL;DR: In this paper, the authors determined changes in the concentrations of caffeine and theobromine in the cocoa pod during its growth, and found that the concentrations increased significantly after about 12 weeks from flowering to the time of harvesting.
Abstract: Changes in the concentrations of caffeine and theobromine in the cocoa pod during its growth were determined. Theobromine and caffeine concentrations increased markedly after about 12 weeks from flowering to the time of harvesting. During the stage when the bean was only a mucilaginous mass, the quantity of caffeine and theobromine was negligible. Caffeine and theobromine levels in the shell, once this is formed, increased rapidly until harvest.

44 citations


Journal ArticleDOI
TL;DR: Serotonin may play a role in the pharmacologic action of caffeine and antiserotonergic drugs were more effective than symphatholytic drugs in preventing alterations in temperature, homeostasis and the lethal consequences of the drug interaction.

34 citations


Journal ArticleDOI
TL;DR: The dominant force of attraction in the 2 : 1 5-chlorosalicylic acid : theobromine crystalline complex is hydrogen bonding as discussed by the authors, and there are three relatively strong hydrogen bonds, all involving a carboxyl group of the salicylate.
Abstract: The dominant force of attraction in the 2 : 1 5-chlorosalicylic acid : theobromine crystalline complex is hydrogen bonding. There are three relatively strong hydrogen bonds, all involving a carboxyl group of the salicylate. A substantial degree of π overlap exists between the phenyl ring of the acid and the xanthine nucleus.

11 citations




Patent
22 Apr 1971
TL;DR: Cardioactive xanthinyl-guanylhydrazones are prepd by conventional methods, pref. by condensing X(CH2)nCR=O with aminoguanidine or its salts.
Abstract: Cardioactive xanthinyl-guanylhydrazones Title cpds. of formula (I) (where X is a xanthine ring such as theophylline or theobromine, R is H, alkyl, opt. substd. aryl or a heterocyclic ring, and n is 1-6) are prepd by conventional methods, pref. by condensing X(CH2)nCR=O with aminoguanidine or its salts. The products have superior cardiac activity to that of the present xanthines and their toxicity is low.

2 citations