Topic
Theobromine
About: Theobromine is a research topic. Over the lifetime, 1137 publications have been published within this topic receiving 29723 citations. The topic is also known as: 3,7-Dimethylxanthine & Theobromin.
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TL;DR: In the spontaneous beating atrium of the cat the purines enhanced both rate and force of contractions; differences in action between theophylline and the other drugs studied were not as pronounced as in papillary muscle.
Abstract: In the electrically driven papillary muscle of the cat's right ventricle theophylline, caffeine and theobromine exerted a positive inotropic action. Log. dose-effect regression lines for the three drugs were parallel; the effect of theophylline was significantly greater than those of caffeine and theobromine. The range of concentrations used was 1/32–1/2 mM/1.
11 citations
TL;DR: Caffeine was selected as the target of the subsequent investigation and its determination was examined in commercially available medicinal drinks and pharmaceutical preparations and it was found that the maximum concentrations of caffeine and 1,7-DMX were obtained at 1-1.5 h and 3-6 h after ingestion, respectively.
11 citations
TL;DR: The data provide ample evidence that the four isolates can be applied to CPH for the purpose of eliminating theobromine and decreasing ochratoxin A content without affecting nutrient profile.
Abstract: Utilization of cocoa pod husks (CPH) in animal feed is hindered by the presence of theobromine, which is variably toxic to animals. Treatment of this agro-waste to remove theobromine, while preserving its nutrient content, would allow beneficial use of the millions of metric tonnes discarded annually. The aim of this study was to assess the suitability of selected theobromine-degrading filamentous fungi for use as bio-tools in degradation of theobromine in CPH. The candidate fungi assessed in this study were an Aspergillus niger (AnTD) and three Talaromyces spp. (TmTD-1, TmTD-2, TvTD) isolates. All the fungi eliminated CPH theobromine, 0.15% w/w starting concentration, within 7 days of start of treatment, and were capable of degrading caffeine and theophylline. The fungi decreased CPH ochratoxin A content by 31–74%. Pectin was not detectable in fungus-treated CPH whereas parameters assessed for proximate composition were not affected. The data provide ample evidence that the four isolates can be applied to CPH for the purpose of eliminating theobromine and decreasing ochratoxin A content without affecting nutrient profile. Comparatively, Talaromyces verruculosus TvTD was considered as most suitable for use as a bio-tool in detheobromination of CPH for animal feed.
11 citations
TL;DR: Results suggested that consumption of caffeine, in low concentrations, mixed with other bioactive molecules along with Li may be safe, despite the controversial nature of caffeine consumption by BD patients.
Abstract: Lithium (Li) is a chemical element used for treating and preventing bipolar disorder (BD) and exerts positive effects such as anti-inflammatory effects as well as undesirable side effects. These effects of Li can be influenced by interaction with some nutritional elements. Therefore, we investigated the potential effects of xanthine (caffeine and theobromine) and catechin molecules present in some food beverages broadly consumed worldwide, such as coffee and tea, on Li-induced anti-inflammatory effects. In the present study, we concomitantly exposed RAW 264.7 macrophages to Li, isolated xanthine and catechin molecules, and a xanthine-catechin mixture (XC mixture). We evaluated the effects of these treatments on cell proliferation, cell cycle progression, oxidative and antioxidant marker expression, cytokine levels, gene expression, and GSK-3β enzyme expression. Treatment with the XC mixture potentialized Li-induced anti-inflammatory effects by intensification of the following: GSK-3β inhibitory action, lowering effect on proinflammatory cytokines (IL-1β, IL-6, and TNFα), and increase in the levels of IL-10 that is an anti-inflammatory cytokine. Despite the controversial nature of caffeine consumption by BD patients, these results suggested that consumption of caffeine, in low concentrations, mixed with other bioactive molecules along with Li may be safe.
11 citations
TL;DR: An overview of the recent molecular spectroscopic work on the methylxanthine alkaloid theobromine and its two closely related relatives, caffeine and theophylline, is presented in this article.
Abstract: An overview of the recent molecular spectroscopic work on the methylxanthine alkaloid theobromine and its two closely related relatives, caffeine and theophylline, is presented. The role of molecular spectroscopy in studies of the coordination chemistry of these methylxanthine compounds is also briefly discussed.
11 citations