Theobromine

About: Theobromine is a research topic. Over the lifetime, 1137 publications have been published within this topic receiving 29723 citations. The topic is also known as: 3,7-Dimethylxanthine & Theobromin.

Pharmacokinetics of theobromine and its metabolites in rabbits

Abstract: The pharmacokinetics of theobromine (3, 7-DMX) and its metabolites was investigated in detail in four male rabbits after bolus intravenous injection (4 mg/kg) of the compound. Apparent first-order rate constants for the metabolic processes involved in the formation of 3,7-DMX metabolites and their excretion in urine were calculated. Theobromine, 7-methylxanthine (7-MX) and 3-methylxanthine (3-MX) were measured in blood and urine, and the other metabolites were determined only in urine. An appropriate model of 14 compartments is formulated to describe the disposition of 3,7-DMX and its metabolites.

Inhibition and enhancement of the noradrenaline constrictor response by methylxanthines.

Abstract: Theophylline and caffeine either inhibited or potentiated the noradrenaline constrictor response in an isolated perfused mesenteric artery preparation. The type of response observed was dependent on both the concentration of noradrenaline and the concentration of methylxanthine. Theobromine produced only inhibition of the noradrenaline response.

Methylxanthines in the group of potassium sensitizers

Abstract: (1950). Les Methylxanthines Dans le Groupe des Sensibilisateurs au Potassium. Archives Internationales de Physiologie: Vol. 57, No. 3, pp. 297-308.

Therapeutic combinations of theobromine and an antihistamine

Abstract: An agent comprises theobromine and an antihistamine, as a combined preparation for simultaneous, sequential or separate use in therapy, particularly in the therapy of cough.