Topic
Theobromine
About: Theobromine is a research topic. Over the lifetime, 1137 publications have been published within this topic receiving 29723 citations. The topic is also known as: 3,7-Dimethylxanthine & Theobromin.
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TL;DR: The isolation of caffeine from coffee is generally assigned to Robiquet, Pelletier and Caventou (1821), though the so-called coffee base, obtained a year previously by Runge was probably impure cafferine as discussed by the authors.
Abstract: The isolation of caffeine from coffee is generally assigned to Robiquet, Pelletier and Caventou (1821), though the so-called coffee base, obtained a year previously by Runge was probably impure cafferine. The identify of theine, extracted from tea by Oudey (1838), with caffeine was established by the analyses of Jobst (1843). The association of caffeine with uric acid was noted originally by Stenhouse, who found the latter in a sample of Paraguay tea.
3 citations
Journal Article•
3 citations
01 Jan 2017
TL;DR: Increased theobromine consumption is unlikely to reduce the risk of cardiovascular disease and combined with other cocoa compounds or consumed by different population groups might have beneficial health effects, however, further research is needed to explore this.
Abstract: Cocoa consumption is associated with a reduced risk of cardiovascular disease (CVD). This beneficial effect may be due to the cocoa compound theobromine. One-time consumption of theobromine showed no beneficial health effects but it did show unfavourably effects on blood insulin levels. Four-week theobromine consumption resulted in a reduction of fasting levels of bad cholesterol, and showed unfavourable effects on postprandial glucose and insulin responses. Theobromine showed no beneficial effects on postprandial fat and cholesterol levels in blood, nor on blood vessel function. Therefore, increased theobromine consumption is unlikely to reduce the risk of cardiovascular disease. Theobromine combined with other cocoa compounds or consumed by different population groups might have beneficial health effects. However, further research is needed to explore this.
3 citations
Patent•
16 Jul 2008
TL;DR: In this article, a 3-methyl xanthine disodium salt methylation with more production value was proposed, where the theobromine was prepared by using acetone as a solvent to react with a dimethyl sulfate under the existence of a sodium carbonate and then acidified.
Abstract: The invention provides a new method for preparing a theobromine by a 3-methyl xanthine disodium salt methylation with more production value. The theobromine is prepared by using acetone as a solvent to react with a dimethyl sulfate under the existence of a sodium carbonate and then acidified. The invention uses the acetone as the solvent and decreases the hydrolysis loss of the dimethyl sulfate; the sodium carbonate provides an alkaline condition for the methylation reaction and the Ph value is intermediate. The dimethyl sulfate is dropped to carry out the methylation reaction with the advantages of good selectivity and a yield higher than other methylation technique by more than 10 percent. The acetone is recycled and reused, the reaction is relatively complete and has little caffeine by-product, and the acquired analysis content of theobromine crude product HPLC is larger than 99 percent. The invention is extremely applicable to industrial production.
3 citations
16 Oct 2017
3 citations