Topic
Theobromine
About: Theobromine is a research topic. Over the lifetime, 1137 publications have been published within this topic receiving 29723 citations. The topic is also known as: 3,7-Dimethylxanthine & Theobromin.
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Journal Article•
TL;DR: The presence of theophylline augmented the increase in baseline tension induced by ouabain, although theophyLLine, by itself, did not augment baseline tension at the concentrations tested.
Abstract: The effects of the combined administration of theophylline and ouabain were examined in isolated right ventricular strips from the rabbit heart. Separately, each drug produced positive inotropism. If ouabain was added 10 minutes after theophylline, a decrease in dF/dt was observed. The presence of theophylline augmented the increase in baseline tension induced by ouabain, although theophylline, by itself, did not augment baseline tension at the concentrations tested. There was a significant correlation between the decrease in dF/dt and the rise in baseline tension. Theophylline did not enhance the ability of ouabain to induce arrhythmia. The actions of caffeine, theobromine and digoxin were also examined and gave similar results.
2 citations
TL;DR: In this paper , the authors examined preconception and pregnancy caffeine exposure with DNAm alterations in neonate cord blood (n = 378) and found no associations with self-reported intake during pregnancy.
2 citations
Journal Article•
2 citations
Journal Article•
TL;DR: Two cDNA fragments of TCS gene were amplified by RT-PCR, and ligated into T-vector, and inserted into RNAi vector pFGC5941 in reverse direction after double digestion with two pairs of restriction endonucleases.
Abstract: Tea Caffeine synthase (TCS) is one of the key enzymes involved in caffieine biosynthsis in tea plant (Camellia sinensis),which catalyses conversions of 7-methylxanthine to theobromine and theobromine to caffeine. Inhibition of TCS gene expression can leads to breeding low caffeine tea cultivars. Two cDNA fragments of TCS gene were amplified by RT-PCR, and ligated into T-vector. The two TCS gene fragments were inserted into RNAi vector pFGC5941 in reverse direction after double digestion with two pairs of restriction endonucleases. The insertion of two fragments, namely pFGC5941-TCS02 and pFGC5941-TCS03, into the RNAi vector were confirmed by PCR and DNA sequencing.
2 citations
Patent•
06 Jul 1979
TL;DR: In this article, a xanthine derivative of formula I was obtained by reacting an easily available compound of formula II (one of R 4 WR 6 is H and the other two are methyl) with an alkyne derivative of HC≡C(CH 2 ) n X (X is halogen).
Abstract: NEW MATERIAL:A xanthine derivative of formula I [one of R 1 WR 3 is HC≡C(CH 2 ) n -, (n is 2W5), and the other two are methyl]. EXAMPLE: 1-(5'-Hexynyl)theobromine. USE: Intermediate of medicines. It has peripheral vessel dilating activity and erythrocyte deformation promoting activity, low toxicity and high solubilty, and is useful as an intermediate of a pharmaceutically valuable xanthine derivative (e.g. pentoxifylline). PROCESS: The compound of formula I is prepared by reacting an easily available compound of formula II (one of R 4 WR 6 is H and the other two are methyl) with an alkyne derivative of formula HC≡C(CH 2 ) n X (X is halogen, etc.). The compound of formula II is, e.g. theobromine, theophylline, etc. The hydration of the titled compound gives a pharmaceutical agent. COPYRIGHT: (C)1981,JPO&Japio
2 citations