Topic
Theobromine
About: Theobromine is a research topic. Over the lifetime, 1137 publications have been published within this topic receiving 29723 citations. The topic is also known as: 3,7-Dimethylxanthine & Theobromin.
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TL;DR: A caffeine degrading bacterium was isolated which is able to grow on media containing up to 2% caffeine as the sole source of carbon and nitrogen and was identified as Pseudomonas putida WS.
Abstract: From soil a caffeine degrading bacterium was isolated which is able to grow on media containing up to 2% caffeine as the sole source of carbon and nitrogen. The organism was identified as Pseudomonas putida and referred to as Pseudomonas putida WS. Mutants of this strain converted caffeine and were shown to accumulate a mixture of theobromine and heteroxanthine during resting cells experiments.
21 citations
TL;DR: The results support Sertoli cells as the primary target cells of theobromine toxicity in rats treated with cocoa extract and could account for the lower toxicity in these animals.
21 citations
TL;DR: The sera of 30 healthy male beagles were analyzed by reversed-phase high-performance liquid chromatography and the chromatograms of each group were very reproducible; however, there were characteristic differences between the two groups.
21 citations
TL;DR: No significant difference was found in the pharmacokinetic profile of the drug after acute or chronic treatment at different doses except for a reduction in the absorption rate constant as the dose increased and AUC values increased in proportion to the dose.
21 citations
TL;DR: A rapid, specific, high-pressure liquid chromatographic method for the determination of theophylline in plasma was developed and the sensitivity, precision, and accuracy are sufficient for routine monitoring of therapeutic levels in patients.
21 citations