Topic
Thin-layer chromatography
About: Thin-layer chromatography is a research topic. Over the lifetime, 7494 publications have been published within this topic receiving 124179 citations. The topic is also known as: TLC.
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TL;DR: The lipophilicity (R(Mo)) and specific hydrophobic surface area of seven 1,2-benzisothiazol-3(2H)-ones have been determined by reversed-phase TLC and the effect of different mobile-phase modifiers on the retention has been studied.
28 citations
TL;DR: In this article, the authors developed methods for the labeling of acetate and palmitic acid with the positron-emitting radionuclide,11C (T = 20.4 min).
Abstract: Methods have been developed for the labelling of acetate and palmitic acid with the positron-emitting radionuclide,11C (T=20.4 min). Labelling was achieved via carbonation of the appropriate alkyl magnesium bromide (methyl magnesium bromide or n-pentadecyl magnesium bromide) with11C-labelled carbon dioxide produced by the14N(p, α)11C nuclear reaction. The radiochemical yield and speed of each method of labelling are such that a radiochemically pure product is obtained in injectable form and in activity (>10 mCi) suitable for the study of myocardial metabolism by emission-computerised axial tomography. High pressure liquid chromatography and thin layer chromatography were used to assess the radiochemical purity of each radiopharmaceutical. The specific activity of11C-labelled acetate was estimated by an enzymic procedure to be greater than 0.5 Ci/μmole.
28 citations
TL;DR: Highly purified aflatoxin G l has been prepared by thin layer chromatography and is a blue fluorescent compound, not, as previously reported, green fluorescent, which does not differ from that of the less pure compound containing a yellow impurity.
Abstract: SummaryA method for quantitative analysis of crude aflatoxin mixtures is described, using thin layer chromatography and absorption spectrometry. Highly purified aflatoxin G l has been prepared by thin layer chromatography and is a blue fluorescent compound, not, as previously reported, green fluorescent. The toxicity of the purified compound does not differ from that of the less pure compound containing a yellow impurity. Both aflatoxins Bl and Gl are fairly stable in aqueous solution in the dark, but undergo rapid decomposition in light (40% in 1 day; almost 100% after 9 days).
28 citations
28 citations
TL;DR: In this paper, the distribution of tannins and flavonoids in E. cicutarium, E. manescavi, and E. pelargoniiflorum were examined by TLC on unmodified silica gel.
Abstract: Natural phenolic compounds, e.g. ellagitannins, gallotannins, and flavonoid glycosides, from the aerial parts of Erodium cicutarium ( Geraniaceae ) have been isolated and identified. The structures of these compounds were determined by conventional methods of analysis and confirmed by MS and NMR spectral analysis. The distribution of tannins and flavonoids in E. ciconium, E. cicutarium, E. manescavi , and E. pelargoniiflorum were examined by TLC on unmodified silica gel and on silica gel chemically modified with polar and nonpolar groups (HPTLC Si 60, HPTLC Si 60 LiChrospher, HPTLC diol, HPTLC CN, and HPTLC RP-18W).
28 citations