Topic
Thin-layer chromatography
About: Thin-layer chromatography is a research topic. Over the lifetime, 7494 publications have been published within this topic receiving 124179 citations. The topic is also known as: TLC.
Papers published on a yearly basis
Papers
More filters
TL;DR: In this article, the causes and factors involved in methyl mercury formation during analysis were investigated using a hyphenate HPLCUV-PCO-CVAFS and a HPLC-ICP-MS technique.
46 citations
TL;DR: When lipid samples from a variety of tissues are run on EDTA-impregnated plates in a solvent system which contains a reduced amount of acetic acid and water, this modified procedure appears to offer significant advantages over the original method described by Skipski et al. particularly for studies of the metabolism of anionic phospholipids.
46 citations
TL;DR: In this article, the lipophilicity of aniline derivatives was determined by reversed-phase thin-layer chromatography using methanol, acetone and acetonitrile as the organic phase.
Abstract: The lipophilicity of aniline and 36 ring-substituted aniline derivatives was determined by reversed-phase thin-layer chromatography using methanol, acetone and acetonitrile as the organic phase. The RM value of each compound linearly decreased with increasing concentration of the organic solvent, Acetonitrile showed the highest and methanol the lowest solvent strength, however, the difference between the solvent strength of methanol and acetone was negligible. The site of the substitution considerably influenced the lipophilicity particularly in the case of −NO2 groups. Good correlation was found between the RM value extrapolated to zero organic phase concentration and the partition coefficient between n-octanol:water. The change in the RM value caused by a 1% increase of the organic phase concentration also correlated with the partition coefficient, however, it was of secondary importance. The lipophilicity parameters determined by reversed-phase thin-layer chromatography correlated to a lesser extent with the calculated lipophilicity values of aniline derivatives.
46 citations
46 citations
46 citations