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Thiourea

About: Thiourea is a(n) research topic. Over the lifetime, 11235 publication(s) have been published within this topic receiving 152407 citation(s). The topic is also known as: thiocarbonic acid diamide & 2-thiourea.

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Journal ArticleDOI
George L. Ellman1Institutions (1)
TL;DR: A study of the specificity of the reaction indicates that it occurs only with the S − group (actual or potential, as in thiourea), and heavy-metal ions interfere with the reaction by irreversibly bonding any S − ions.

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Abstract: 1. 1. A method for the determination of mercaptans is described. It depends on the interchange of bis( p -nitrophenyl)disulfide and mercaptan anions at pH 8.0. 2. 2. A study of the specificity of the reaction indicates that it occurs only with the S − group (actual or potential, as in thiourea). 3. 3. Heavy-metal ions interfere with the reaction by irreversibly bonding any S − ions. 4. 4. The kinetics of the reaction with cysteine and β-mercaptoethylamine were studied. 5. 5. Several applications of this reaction were made: ( a ) the determination of mercaptan in synthetic compounds; ( b ) mercaptan reactivity in proteins; and ( c ) determination of blood and serum concentrations.

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1,023 citations


Journal ArticleDOI
Tomotaka Okino1, Yasutaka Hoashi1, Tomihiro Furukawa1, Xuenong Xu1  +1 moreInstitutions (1)
TL;DR: A new class of bifunctional catalysts bearing a thiourea moiety and an amino group on a chiral scaffold bearing 3,5-bis(trifluoromethyl)benzene and dimethylamino groups was revealed to be highly efficient for the asymmetric Michael reaction of 1,3-dicarbonyl compounds to nitroolefins.

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Abstract: We synthesized a new class of bifunctional catalysts bearing a thiourea moiety and an amino group on a chiral scaffold. Among them, thiourea 1e bearing 3,5-bis(trifluoromethyl)benzene and dimethylamino groups was revealed to be highly efficient for the asymmetric Michael reaction of 1,3-dicarbonyl compounds to nitroolefins. Furthermore, we have developed a new synthetic route for (R)-(-)-baclofen and a chiral quaternary carbon center with high enantioselectivity by Michael reaction. In these reactions, we assumed that a thiourea moiety and an amino group of the catalyst activates a nitroolefin and a 1,3-dicarbonyl compound, respectively, to afford the Michael adduct with high enantio- and diastereoselectivity.

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884 citations


Journal ArticleDOI
Abstract: Converting solar energy into hydrogen gas by water splitting is considered as a long-term solution to address global energy and environmental problems. Great effort has been devoted to the search for abundant systems for the purpose of efficient capture, conversion, and storage of solar energy in a cost-effective manner. To further advance the recently-developed carbon nitride photocatalysis for solar hydrogen generation, thiourea, a sulfur-containing compound, was used as a cheap and easily-available starting material for the synthesis of graphitic carbon nitride semiconductors. The as-prepared photocatalysts were subjected to several characterizations, and the results showed that the heating temperature and the presence of sulfur motifs offer a facile chemical pathway for the control of the condensation/polymerization of carbon nitride, and thus adjusting their textural and electronic properties. Photocatalytic activity experiments demonstrated that the g-C3N4 synthesized from thiourea exhibited a much higher H2 production rate than that of g-C3N4 prepared from dicyanamide or urea, and this activity can be further enhanced by increasing the condensation temperature.

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682 citations


Journal ArticleDOI
Yoshiji Takemoto1Institutions (1)
TL;DR: Enantioselective reactions catalyzed by urea and thiourea derivatives as general acid catalysts as well as diastereoselectives reactions are described.

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Abstract: Hydrogen-bonding interaction plays a crucial role in the molecular recognition and activation processes of various biologically important reactions that are mediated by enzymes and antibodies in living organisms. Recently, it has been shown that a hydrogen-bonding donor can be used as a general acid catalyst for various types of reactions in organic chemistry. In this article, we describe enantioselective reactions catalyzed by urea and thiourea derivatives as general acid catalysts as well as diastereoselective reactions. This perspective provides an overview of this rapidly growing field.

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655 citations



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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20229
2021250
2020318
2019364
2018355
2017376

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Topic's top 5 most impactful authors

Yoshiji Takemoto

42 papers, 2.7K citations

Bohari Mohd. Yamin

23 papers, 110 citations

Amin Badshah

17 papers, 380 citations

Aamer Saeed

15 papers, 313 citations

Ulrich Flörke

14 papers, 308 citations