Topic
Toad
About: Toad is a research topic. Over the lifetime, 1624 publications have been published within this topic receiving 28732 citations.
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TL;DR: The response to norepinephrine was studied in isolated skins of a semiaquatic frog, known to maintain indispensable skin moisture by secreting a superficial film of mucus via sympathetic stimulation of skin glands, and a terrestrial toad, found to be consistent with the postulated involvement of frog skin glands in sulfate excretion.
15 citations
TL;DR: Two novel bioactive peptides were purified from skin secretions of the toad Bombina maxima and exhibit 86-91% sequence identity with Bv8, a peptide originally isolated from skinSecretions of Bombina variegata.
Abstract: Two novel bioactive peptides were purified from skin secretions of the toad Bombina maxima. The partial N-terminal sequences of these two peptides were determined by automated Edman degradation. This allowed the cloning of full-length cDNAs encoding these two peptides from a cDNA library prepared from the toad skin. The deduced complete amino acid sequences indicate that both peptides are composed of 77 amino acids. A fasta search in the databanks revealed that they exhibit 86–91% sequence identity with Bv8, a peptide originally isolated from skin secretions of Bombina variegata. They were thus named as Bv8-like peptide 1 (Bv8-LP1) and Bv8-like peptide 2 (Bv8-LP2), respectively. Sequence differences between Bv8-LP1 and 2 were due to six amino acid substitutions at positions 6, 11, 23, 24, 62 and 63. Bv8-LP1 and 2 differed from Bv8 with eleven and seven amino acid substitutions, respectively. Like Bv8, Bv8-LP1 and 2 possessed contractile activity on isolated guinea pig ileum. Additionally, they stimulated contraction of rabbit aortic rings in a dose-dependent manner at nanomolar concentrations.
15 citations
TL;DR: A preliminary report showing that both water transport and oxygen uptake of the isolated bladder of the toad Bufo bufo are influenced by thyroxine.
Abstract: VIRTUALLY nothing is known of the role of thyroxine in the cellular metabolism of adult Amphibia. Though insulin1 and vasopressin2 have received much recent attention as hormones which effect permeability of cells, thyroidal hormones have not hitherto been shown to have this effect. The following is a preliminary report showing that both water transport and oxygen uptake of the isolated bladder of the toad Bufo bufo are influenced by thyroxine.
15 citations
TL;DR: The results suggest that in the toad sinus venosus, two distinct transduction pathways can be activated by epinephrine to cause an increase in heart rate.
Abstract: This study examined the transduction pathways activated by epinepherine in the pacemaker region of the toad heart. Recordings of membrane potential, force, and intracellular Ca2+ concentration ([Ca...
15 citations
TL;DR: The results suggest that most vertebrates tested are sensitive to SRTX/ET, while the snake may possess receptors that are of a different structure.
15 citations