Topic
Toad
About: Toad is a research topic. Over the lifetime, 1624 publications have been published within this topic receiving 28732 citations.
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Journal Article•
TL;DR: Histochemical techniques for acid phosphatase activity applied to kidney tissue of the toad Bufo bufo demonstrate that a high enzyme activity is present in the dense granules of the proximal tubule cells, but also in the media cells in the wall of the glomerular afferent arterioles.
Abstract: Histochemical techniques for acid phosphatase activity applied to kidney tissue of the toad Bufo bufo demonstrate that a high enzyme activity is present in the dense granules of the proximal tubule cells, but also in the media cells in the wall of the glomerular afferent arterioles. The acid phosphatase activity is confined to the characteristic granules in these juxtaglomerular cells, which therefore are lysosomal in nature.
2 citations
Patent•
03 Apr 2013
TL;DR: A total unsaturated toad lactone, and a preparation method and a use thereof was disclosed in this paper, which has the activity of inhibiting male sex hormone dependent form prostate cancer cell multiplication.
Abstract: The invention discloses a total unsaturated toad lactone, and a preparation method and a use thereof The preparation method for the total unsaturated toad lactone comprises the following steps: (1), crushing the toad, ultrasonically extracting the crushed toad 3-4 times using ethanol solution, and filtering to remove the dredges to obtain the toad extracting solution; (2), concentrating the toad extracting solution under reduced pressure to obtain pulp as the toad total extract; (3), suspending the toad total extract with water, extracting the suspended toad total extract using dichloromethane, and evaporating under reduced pressure to remove dichloromethane to obtain the dichloromethane part; and (4), dissolving the dichloromethane part with a solvent A and regulating the pH value of the solution to 1-6, stirring and reacting the solution for 1-8 hours at a temperature of 0 DEG C to 100 DEG C, adding water to stop the reaction when at least two compounds of Bu-1, Bu-2, Bu-3, Bu-4 and Bu-5 in the solution are detected, extracting using a solvent B, and evaporating under reduced pressure to remove the solvent B to obtain the total unsaturated toad lactone The total unsaturated toad lactone disclosed by the invention has the activity of inhibiting male sex hormone dependent form prostate cancer cell multiplication and non-male sex hormone dependent form prostate cancer cell multiplication, and can be used for preparing the medicine for preventing and treating the prostate cancer
2 citations
TL;DR: This paper reports the response of the narrow-mouthed toad to forelimb amputation, and the amputation wound was closed by epidermal migration within 24 h.
Abstract: This paper reports the response of the narrow-mouthed toad, Gastrophryne carolinensis, to forelimb amputation. The amputation wound was closed by epidermal migration within 24 h. Within the 1st wee...
2 citations
Journal Article•
TL;DR: Toad vonem and verapamil have analgesic synergism, and both toad venom and T-V compound had remarkable analgestic effect on pain in mice induced by acetic acid and hot-plate.
Abstract: Objective To research synergetic analgesic effect of toad venom and verapamil. Methods Acetic acid caused body turning experiment and hot plate-induced pain experiment were used to observe analgesic effect, and the influence of action potential of toad sciatic nerve was observe by nerve chamber and multi-media MS-302 system. Results Toad venom and T-V(toad venom-verapamil) compound had remarkable analgestic effect on pain in mice induced by acetic acid and hot-plate. T-V compound had greater effect on analgesia. Verapamil has faint analgestic effect. Both toad venom and T-V compound were not able to inhibit action potential transmission of toad sciatic nerve. Conclusion Toad vonem and verapamil have analgesic synergism.
2 citations