Showing papers on "Total synthesis published in 1983"
292 citations
198 citations
TL;DR: The generality and efficiency of the reiterative two-carbon extension cycle methodology are demonstrated in the total synthesis of all eight L-hexoses.
Abstract: Enantiomerically pure polyhydroxylated natural products are synthesized by using a reiterative two-carbon extension cycle consisting of four steps. The generality and efficiency of this methodology are demonstrated in the total synthesis of all eight L-hexoses.
133 citations
TL;DR: In this paper, a practical, stereocontrolled synthesis of leukotriene B5 is described, which makes this substance readily available for the first time and can be used for medical applications.
111 citations
82 citations
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62 citations
TL;DR: In this article, a new synthesis of cis-3a-aryloctahydroindoles is described, where the key step is a ring-enlarging pyrrolidine annulation reaction which occurs when 2-amino-1-(1-arylethenyl)cyclopentanols are treated under mild conditions with an aldehyde and acid.
Abstract: A new synthesis of cis-3a-aryloctahydroindoles is detailed. The key step is a ring-enlarging pyrrolidine annulation reaction which occurs when 2-amino-1-(1-arylethenyl)cyclopentanols are treated under mild conditions with an aldehyde and acid. Three different methods (Schemes I-III) for assemblying the 2-amino(1-arylethenyl)cyclopentanol intermediates are reported. An efficient formal total synthesis of the Amaryllidaceae alkaloid (+-)-crinine (Scheme III) is reported, in which key intermediate 26 was assembled with virtually complete stereocontrol in four steps and 44% overall yield from readily available 1,2-bis(trimethylsilyoxy)cyclopentene.
TL;DR: On prepare une benzo [e] indenone, intermediaire de synthese de la cortisone, a partir du borneol (−) as mentioned in this paper.
Abstract: On prepare une benzo [e] indenone, intermediaire de synthese de la cortisone, a partir du borneol (−)
TL;DR: Synthese regiospecifique du compose cite avec comme etape cle la condensation d'une acetyl-6 naphtalenone-1 avec l'anion de la benzenesulfonyl-3 dihydro-1,3 methoxy-7 benzo [c] furannone -1 as discussed by the authors.
Abstract: Synthese regiospecifique du compose cite avec comme etape cle la condensation d'une acetyl-6 naphtalenone-1 avec l'anion de la benzenesulfonyl-3 dihydro-1,3 methoxy-7 benzo [c] furannone-1
TL;DR: The first total synthesis of racemic neplanocin A (1)1 from cyclopentadiene and acylnitroso-3,5-dinitrobenzoic acid is described in this paper.
Abstract: The first total synthesis of racemic neplanocin A (1)1 from cyclopentadiene and acylnitroso-3,5-dinitrobenzoic acid is described. The synthesis is suitable for specific isotopic labelling of the hydroxymethyl group of neplanocin A.
TL;DR: In this paper, an efficient synthesis of functionalized trialkyl substituted cyclopentanoids is presented, secured by their formation from norbornane precusors, which is illustrated by the total synthesis of (±)-boschnialactone (13 ), (±-teucriumlactone C ( 14 ) and (±]-loganin ( 2 ).
TL;DR: The optically active plant product homaline has been synthesized in a convergent sequence starting with β-phenyl-β-alanine and putrescine as mentioned in this paper.