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Total synthesis
About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.
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TL;DR: Poly-L-leucine catalyses the asymmetric epoxidation of enones 1−6 efficiently in a nonaqueous medium to provide the epoxy ketones 7−12 (70-91% yield; 80 to 95% ee) as mentioned in this paper.
Abstract: Poly-L-leucine catalyses the asymmetric epoxidation of enones 1–6 efficiently in a non-aqueous medium to provide the epoxy ketones 7–12 (70–91% yield; 80 to 95% ee). The strategy was used to make diltiazem 16 and the TaxolTM side chain 23 in single enantiomer form.
110 citations
TL;DR: A Pd-catalyzed Larock annulation provides expedient access to a subset of resveratrol-derived natural products and resulted in the structural revision of an intermediate en route to the natural product pauciflorol F.
110 citations
TL;DR: In this article, a method for heterocycles from terminal alkynes containing suitably positioned heteroatoms was developed, using this alkylative carboxylation followed by a hetero-Michael reaction.
110 citations
TL;DR: The first total synthesis of (+)-broussonetine G, a potent glycosidase inhibitor, is described along with the assignment of its relative and absolute stereochemical configuration.
Abstract: Palladium catalyzed asymmetric allylic alkylation reaction of an amine with two equivalents of butadiene monoxide allows for the expedient synthesis of trans- and cis-2,5-dihydropyrroles. The versatility of these chiral synthons towards the synthesis of a wide variety of iminosugar natural products was demonstrated with the short and high yielding asymmetric syntheses of (+)-DMDP, and (-)-bulgecinine. In addition, the first total synthesis of (+)-broussonetine G, a potent glycosidase inhibitor, is described along with the assignment of its relative and absolute stereochemical configuration.
110 citations
TL;DR: Synthese a partir de spermidine protegee et de (N 1,N 2 -di-t-butoxycarbonyl S-methyl) thiocarbamimidate as mentioned in this paper.
Abstract: Synthese a partir de spermidine protegee et de (N 1 ,N 2 -di-t-butoxycarbonyl S-methyl) thiocarbamimidate
110 citations