scispace - formally typeset
Search or ask a question
Topic

Total synthesis

About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: A convergent enantioselective synthesis of the natural product (-)-callystatin A is described, using a lipase-mediated kinetic resolution to install the C5 lactone stereochemistry and a hydrozirconation-based approach to the C8-C9 trisubstituted (Z)-olefin.

102 citations

Journal ArticleDOI
TL;DR: Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized using an intramolecular Staudinger reduction/aza-Wittig process for the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety.
Abstract: Apratoxin A, a cyclodepsipeptide isolated from cyanobacterial Lyngbya spp, has been synthesized. The total synthesis features stereocontrolled access to the novel polyketide and the late-stage installation of the sensitive 2,4-disubstituted thiazoline moiety using an intramolecular Staudinger reduction/aza-Wittig process.

102 citations

Journal ArticleDOI
TL;DR: The synthesis features three oxidative reactions as key steps in a biomimetic manner, involving an AgOAc-mediated oxidative coupling reaction to construct the pyrrole core, a Pb(OAc)(4)-induced oxidative cyclization to form the lactone, and Kita's oxidation reaction to formThe pyr role-arene C-C bond.

101 citations


Network Information
Related Topics (5)
Cycloaddition
39.9K papers, 728.7K citations
98% related
Enantioselective synthesis
58.1K papers, 1.6M citations
98% related
Aryl
95.6K papers, 1.3M citations
97% related
Intramolecular force
41.6K papers, 772.2K citations
93% related
Lewis acids and bases
29.5K papers, 631.7K citations
93% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023245
2022592
2021479
2020451
2019497
2018551