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Total synthesis

About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the authors used Hinsberg-type pyrrole synthesis and palladium-catalyzed Suzuki-Miyaura coupling of the 3,4-dihydroxypyrrole bistriflate 6 as the key reactions.

90 citations

Journal ArticleDOI
TL;DR: The total synthesis of (+/-)-dibromophakellstatin is described, constructed from a key syn-diazide, formed by a hypervalent iodine-mediated diazidation of a dihydrodipyrrolopyrazinone ring structure.

90 citations

Journal ArticleDOI
TL;DR: In this paper, a total synthesis of the biologically important diterpene ingenol has been completed, and a ring-closing olefin metathesis was used to construct the strained "inside-outside" tetracyclic skeleton.
Abstract: A total synthesis of the biologically important diterpene ingenol has been completed. Ring-closing olefin metathesis was used to construct the strained "inside-outside" tetracyclic skeleton, and a series of diastereoselective reactions were employed to complete the synthesis. Another naturally occurring ingenane, 20-deoxyingenol, has also been prepared.

90 citations

Journal ArticleDOI
TL;DR: A synthesis of the antimitotic alkaloids (-)-colchicine and (-)-isocolchicines is reported, which opens an efficient enantioselective access to colchichine and structural analogues.

90 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023245
2022592
2021479
2020451
2019497
2018551