Topic
Total synthesis
About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.
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TL;DR: The total synthesis of the spiroketal ionophore antibiotic routiennocin 1 (CP-61,405) employing π-allyltricarbonyl iron lactone complexes is described in this paper.
89 citations
TL;DR: In this article, the allyl moiety of 3-allyl-3-hydroxyindolin-2-one alkaloids was transformed by transformation of allyl mixtures.
89 citations
TL;DR: A virtually complete asymmetric control in the synthesis of 2,3-disubstituted butan-4-olide (10) was demonstrated by employing the butenolide as the chiral acceptor for the conjugate 1,4-addition as discussed by the authors.
89 citations
TL;DR: (+/-)-Aspidospermidine has been synthesized from readily available methyl 3-ethyl-2-oxocylo-pentanecarboxylate in 5.9% yield over 13 steps using an intramolecular cascade reaction.
Abstract: (±)-Aspidospermidine (1) has been synthesized from readily available methyl 3-ethyl-2-oxocylopentanecarboxylate (17) in 5.9% yield over 13 steps. The key step of the synthesis is an intramolecular cascade reaction that simultaneously forms the B, C, and D rings of 1. A high-yielding method of closing the remaining E ring is also described.
89 citations
89 citations