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Total synthesis
About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.
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198 citations
TL;DR: The inter- and intramolecular Diels-Alder reactions of in situ generated masked o-benzoquinones produced cycloadducts in excellent selectivities and the efficacy of the methodology is demonstrated by several examples of the total synthesis of natural products.
Abstract: An account of the synthetic utility of masked o-benzoquinones is provided. The inter- and intramolecular Diels-Alder reactions of in situ generated masked o-benzoquinones produced cycloadducts in excellent selectivities. New synthetic methodologies have been developed for the synthesis of highly substituted ring systems including bicyclo[2.2.2]octenones, oxatricycles, triquinanes, polysubstituted cyclohexanes, and bicyclo[4.2.2]decenones with complete stereocontrol from easily accessible 2-methoxyphenols via the Diels-Alder reaction of masked o-benzoquinones. Other reactions of adducts derived from masked o-benzoquinones are also described. The efficacy of our methodology is demonstrated by several examples of the total synthesis of natural products.
197 citations
196 citations
196 citations
TL;DR: A convergent asymmetric synthesis of the calcium ionophore ionomycin has been achieved through a route that is outlined in this paper, where the four illustrated subunits, which comprise the c,C,,-,, CI)-&r cI&22, and C=-C32 portions of ionomecin, are presented.
Abstract: A convergent asymmetric synthesis of the calcium ionophore ionomycin has been achieved through a route that is outlined below. The four illustrated subunits, which comprise the c,-C,,-,, CI)-&r cI&22, and C=-C32 portions of ionomycin,
195 citations