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Total synthesis
About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.
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149 citations
TL;DR: In this paper, 3-substituted isoquinolines and pyridines were synthesized by coupling aryl, alkenyl, and alkyl substituents with the tert-butylimines of o-iodobenzaldehydes or 3-halo-2-alkenals.
149 citations
TL;DR: A concise first total synthesis of (±) maoecrystal V is reported, which features a Wessely oxidative dearomatization of a phenol, an intramolecular Diels-Alder reaction, and a Rh-catalyzed O-H bond insertion as key steps.
Abstract: A concise first total synthesis of (±) maoecrystal V (1) is reported. The synthesis features a Wessely oxidative dearomatization of a phenol, an intramolecular Diels-Alder reaction, and a Rh-catalyzed O-H bond insertion as key steps.
149 citations
TL;DR: The first total synthesis of racemic perophoramidine is described, which features the highly stereoselective introduction of the vicinial quaternary centers via base-promoted carbon-carbon bond formation between a 3-alkylindole and a3-bromo-3-alksylindolin-2-one intermediate.
Abstract: The first total synthesis of racemic perophoramidine is described. The key step features the highly stereoselective introduction of the vicinial quaternary centers via base-promoted carbon−carbon bond formation between a 3-alkylindole and a 3-bromo-3-alkylindolin-2-one. This transformation presumably proceeds through a conjugate addition or Diels−Alder cycloaddition of the 3-alkylindole with a 3-alkylindol-2-one intermediate.
149 citations
148 citations