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Total synthesis

About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.


Papers
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Journal ArticleDOI
TL;DR: Recent advances and examples of the intramolecular Diels-Alder reaction are summarized and applications to the total synthesis of natural products, both completed and in progress, noted as discussed by the authors.
Abstract: Recent advances and examples of the intramolecular Diels–Alder reaction are summarized and applications to the total synthesis of natural products, both completed and in progress, noted. A detailed...

296 citations

Journal ArticleDOI
TL;DR: An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished and was completed in nine chemical steps and 21% overall yield.
Abstract: An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels−Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidinyl ring system. This total synthesis of (+)-minfiensine was completed in nine chemical steps and 21% overall yield.

294 citations

Journal ArticleDOI
TL;DR: This review surveys total syntheses of sulfur-containing natural products that introduce sulfur atoms using different sulfurization agents to construct related sulfur- containing moieties.

291 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023245
2022592
2021479
2020451
2019497
2018551