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Total synthesis
About: Total synthesis is a research topic. Over the lifetime, 25578 publications have been published within this topic receiving 489319 citations.
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TL;DR: The total synthesis of β-corticotropin, with the amino-acid sequence characteristic of the porcine species, has been achieved using methods especially designed and developed for preparing large and complicated peptides.
Abstract: THE total synthesis of β-corticotropin (ACTH), with the amino-acid sequence characteristic of the porcine species1 (Fig. 1), has been achieved2 using methods especially designed and developed for preparing large and complicated peptides3. They are: (a) formation of peptide bonds mainly by means of active esters4 (for example, p-nitrophenyl esters5,6); (b) protection of amino and carboxyl functions with such blocking groups derived from t-butanol that easily can be removed in the last stage of the synthesis without destruction of sensitive peptides3.
111 citations
111 citations
TL;DR: In this paper, a practical, stereocontrolled synthesis of leukotriene B5 is described, which makes this substance readily available for the first time and can be used for medical applications.
111 citations
111 citations
111 citations