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Transcription (biology)

About: Transcription (biology) is a research topic. Over the lifetime, 56532 publications have been published within this topic receiving 2952782 citations. The topic is also known as: genetic transcription & transcription, genetic.


Papers
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Journal ArticleDOI
TL;DR: The data suggest that AGO4 is guided to target loci through base-pairing of associated siRNAs with nascent Pol V transcripts, and that DEFECTIVE in MERISTEM SILENCING3, a structural maintenance of chromosomes (SMC) hinge-domain protein, functions in the assembly of Pol V transcription initiation or elongation complexes.
Abstract: Craig Pikaard and colleagues show that AGO4 is recruited to target loci through physical interactions with nascent RNA polymerase V transcripts. They also show that the SMC hinge-domain protein DMS3 functions in the assembly of Pol V transcription complexes.

442 citations

Journal ArticleDOI
24 May 2007-Nature
TL;DR: Transcription in heterochromatin seems to be an oxymoron — surely the 'silenced' form of chromatin should not be transcribed, but there have been frequent reports of low-level transcription inheterochromatic regions, and several hundred genes are found in these regions in Drosophila.
Abstract: Transcription in heterochromatin seems to be an oxymoron--surely the 'silenced' form of chromatin should not be transcribed. But there have been frequent reports of low-level transcription in heterochromatic regions, and several hundred genes are found in these regions in Drosophila. Most strikingly, recent investigations implicate RNA interference mechanisms in targeting and maintaining heterochromatin, and these mechanisms are inherently dependent on transcription. Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction.

441 citations

Journal ArticleDOI
14 Jul 2006-Cell
TL;DR: It is hypothesized that maintenance of the heterochromatic state involves locus-specific Pol IVa transcription followed by siRNA production and assembly of AGO4- and NRPD1b-containing silencing complexes within nucleolar processing centers.

441 citations

Journal ArticleDOI
TL;DR: Evidence is emerging to suggest that transcription factors lacking a MBD can also interact with methylated DNA, and the identification of these proteins and the elucidation of their characteristics and the biological consequences are important stepping stones towards a mechanistic understanding of methylation-mediated biological processes.
Abstract: Recent technological advances have made it possible to decode DNA methylomes at single-base-pair resolution under various physiological conditions. Many aberrant or differentially methylated sites have been discovered, but the mechanisms by which changes in DNA methylation lead to observed phenotypes, such as cancer, remain elusive. The classical view of methylation-mediated protein-DNA interactions is that only proteins with a methyl-CpG binding domain (MBD) can interact with methylated DNA. However, evidence is emerging to suggest that transcription factors lacking a MBD can also interact with methylated DNA. The identification of these proteins and the elucidation of their characteristics and the biological consequences of methylation-dependent transcription factor-DNA interactions are important stepping stones towards a mechanistic understanding of methylation-mediated biological processes, which have crucial implications for human development and disease.

441 citations

Journal ArticleDOI
TL;DR: It is reported that, in contrast to estrogen receptor transcription complexes which form within minutes and recycle hourly, the levels of regulatory regions bound by AR complexes rise over a 16 hr period and then slowly decline.

441 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
20229
20211,730
20201,721
20191,686
20181,571
20171,465