Topic
Transcription (biology)
About: Transcription (biology) is a research topic. Over the lifetime, 56532 publications have been published within this topic receiving 2952782 citations. The topic is also known as: genetic transcription & transcription, genetic.
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TL;DR: These co-transcriptional silencing mechanisms form powerful RNA surveillance systems that detect and silence inappropriate transcription events, and provide a memory of these events via self-reinforcing epigenetic loops.
Abstract: Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding Argonaute-containing complexes to complementary nascent RNA scaffolds and then mediating the recruitment of histone and DNA methyltransferases. In addition, recent advances suggest that chromatin-associated long non-coding RNA scaffolds also recruit chromatin-modifying complexes independently of small RNAs. These co-transcriptional silencing mechanisms form powerful RNA surveillance systems that detect and silence inappropriate transcription events, and provide a memory of these events via self-reinforcing epigenetic loops.
842 citations
TL;DR: A novel DNA-sensing pathway involving RNA polymerase III and RIG-I is identified, which was important in the sensing of Epstein-Barr virus–encoded small RNAs, which were transcribed by RNA polymer enzyme III and then triggered Rig-I activation.
Abstract: After binding double-stranded RNA, RIG-I induces production of type 1 interferon. Hornung and colleagues find that RIG-I detects viral DNA via double-stranded RNA intermediates generated by RNA polymerase III.
840 citations
TL;DR: A cascade of gene activation from maternal RNA/protein sets to zygotic genome activation and thence to MGA gene sets is proposed, which is a first step toward analysis of the complex gene regulatory networks.
839 citations
TL;DR: Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage, and complementary DNA encoding the murine protein is identified using high-level transient expression in mammalian cells.
Abstract: Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man.
837 citations
TL;DR: Two short regions of GAL4 are identified, each of which activates transcription when fused to the DNA-binding region of the molecule, which is not required for gene activation.
834 citations