Showing papers on "Transcription factor published in 1973"
TL;DR: The isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli is reported, suggesting that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3':5'-cyclic GMP in addition to their normal effector.
Abstract: We report here the isolation of an extragenic suppressor of a promoter mutation in the lactose operon of Escherichia coli Genetic data have indicated that the suppressor of the P- mutation maps in the structural gene for the transcription factor catabolite activator protein Biochemical studies suggest that the mutant molecules of catabolite activator protein are altered in such a way that they are activated by 3′:5′-cyclic GMP in addition to their normal effector, 3′:5′-cyclic AMP
31 citations