Topic
Transplantation
About: Transplantation is a research topic. Over the lifetime, 276584 publications have been published within this topic receiving 7961661 citations.
Papers published on a yearly basis
Papers
More filters
TL;DR: It is shown that the tuberous sclerosis complex-mammalian target of rapamycin (TSC-mTOR) pathway regulated inflammatory responses after bacterial stimulation in monocytes, macrophages, and primary dendritic cells, and protected genetically susceptible mice against lethal Listeria monocytogenes infection.
716 citations
TL;DR: When incorporated into high-dose therapy for myeloma, thalidomide increased the frequency of complete responses and extended event-free survival at the expense of added adverse effects without improving overall survival.
Abstract: Background High-dose therapy with melphalan can prolong survival among patients with multiple myeloma We assessed whether the addition of thalidomide, which has activity against advanced and refractory myeloma, would further improve survival Methods Between October 1998 and February 2004, 668 patients with newly diagnosed multiple myeloma received two cycles of intensive melphalan-based chemotherapy, each supported by autologous hematopoietic stem-cell transplantation A total of 323 were randomly assigned to receive thalidomide from the outset until disease progression or undue adverse effects, and 345 did not receive thalidomide The primary end point was the five-year event-free survival rate Secondary end points were complete response and overall survival Results After a median follow-up of 42 months among survivors, the thalidomide and control groups had rates of complete response of 62 percent and 43 percent, respectively (P<0001), and five-year event-free survival rates of 56 percent and 44 percent (P = 001) The five-year rate of overall survival was approximately 65 percent in both groups (P = 090) Median survival after relapse was 11 years in the thalidomide group and 27 years in the control group (P = 0001) Severe peripheral neuropathy and deep-vein thrombosis occurred more frequently in the thalidomide group than in the control group Conclusions When incorporated into high-dose therapy for myeloma, thalidomide increased the frequency of complete responses and extended event-free survival at the expense of added adverse effects without improving overall survival (ClinicalTrialsgov number, NCT00083551)
716 citations
TL;DR: It is shown that adipocyte-specific deletion of the coregulatory protein PRDM16 caused minimal effects on classical brown fat but markedly inhibited beige adipocyte function in subcutaneous fat following cold exposure or β3-agonist treatment, indicating that PRDM 16 and beige fat cells are required for the "browning" of white fat and the healthful effects of sub cutaneous adipose tissue.
716 citations
Journal Article•
716 citations
TL;DR: Evidence is provided of the clinical usefulness of ex vivo purging of autologous bone marrow in the treatment of patients with lymphoma and suggest that the reinfusion of malignant cells in autOLOGous marrow contributes to relapse.
Abstract: Background. The use of autologous bone marrow transplantation is increasing in the management of advanced cancers. Many investigators have attempted to "purge" autologous marrow of residual tumor cells because of concern that reinfused tumor cells might contribute to relapse. The efficacy of purging remains unproved. Methods. We performed clonogenic assays in a tumor cell line in culture to determine the efficiency of immunologic purging. Amplification by the polymerase chain reaction (PCR) was used to detect residual lymphoma cells before and after purging of bone marrow from 114 patients with B-cell non-Hodgkin's lymphoma in whom a translocation (t(14;18)) that could be amplified by PCR was detected at the time of their initial evaluation. Results. Immunologic purging in vitro resulted in a 3-to-6-log destruction of cells in the tumor cell line. Residual lymphoma cells were detected by PCR in the bone marrow of all patients before purging. No lymphoma cells could be detected in the marrow of 57...
716 citations