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Transplantation

About: Transplantation is a research topic. Over the lifetime, 276584 publications have been published within this topic receiving 7961661 citations.


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Journal ArticleDOI
TL;DR: Among patients with newly diagnosed multiple myeloma who were ineligible for autologous stem-cell transplantation, the risk of disease progression or death was significantly lower among those who received daratumumab plus lenalidomide and dexamethasone than among thosewho received lenalidmide and Dexameth asone alone.
Abstract: Background Lenalidomide plus dexamethasone is a standard treatment for patients with newly diagnosed multiple myeloma who are ineligible for autologous stem-cell transplantation. We sought...

609 citations

Journal ArticleDOI
TL;DR: The deliberations of the Subcommittee in identifying priorities for a new lung allocation system, the analyses undertaken by the OPTN and the Scientific Registry for Transplant Recipients and the evolution of a new Lung Allocation Score, incorporating waiting list and posttransplant survival probabilities are reviewed.

609 citations

Journal ArticleDOI
TL;DR: These results offer compelling evidence that the major environmental impediment to regeneration in the adult CNS is the molecular barrier that forms directly at the lesion site, and that degenerating white matter beyond the glial scar has a far greater intrinsic ability to support axon regeneration than previously thought possible.
Abstract: We have recently reported that minimally disturbed adult CNS white matter can support regeneration of adult axons by using a novel microtransplantation technique to inject minute volumes of dissociated adult rat dorsal root ganglion neurons directly into adult rat CNS pathways (Davies et al., 1997). This atraumatic injection procedure minimized scarring and allowed considerable numbers of regenerating adult axons immediate access to the adult CNS glial terrain where they rapidly extended for long distances. A critical question remained as to whether degenerating white matter at acute and chronic stages (up to 3 months) after injury could still support regeneration. To investigate this, we have microtransplanted adult sensory neurons into degenerating white matter of the adult rat spinal cord several millimeters rostral to a severe lesion of the dorsal columns. Regeneration of donor sensory axons in both directions away from the site of transplantation was robust even within white matter undergoing fulminant Wallerian degeneration despite intimate contact with myelin. Along their route, the regrowing axons extended large numbers of collaterals into the adjacent dorsal horn. However, after entering the lesion, the rapidly extending growth cones stopped and became dystrophic within high concentrations of reactive glial matrix. Our results offer compelling evidence that the major environmental impediment to regeneration in the adult CNS is the molecular barrier that forms directly at the lesion site, and that degenerating white matter beyond the glial scar has a far greater intrinsic ability to support axon regeneration than previously thought possible.

608 citations

Journal ArticleDOI
TL;DR: It is shown that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia, but does not control erbB3 expression as in peripheral glia, and functions in peripheral and central glia at different stages and through different mechanisms.
Abstract: Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted. No myelin was generated upon transplantation of Sox10-deficient neural stem cells into wild-type hosts showing the permanent, cell-autonomous nature of the defect. Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms.

608 citations

Book
15 Jan 1996
TL;DR: Infectious Diseases: Epidemiology & Control of Infectious Diseases, Prevention ofinfectious diseases, and Infections and Cancer.
Abstract: PART 1 UNDERSTANDING, CONTROLLING & PREVENTING INFECTIOUS DISEASES: Epidemiology & Control of Infectious Diseases. Prevention of Infectious Diseases PART II CLINCAL SYNDROMES & CARDINAL FEATURES of INFECTIOUS DISEASES: APPROACH to DIAGNOSIS & INITITIAL MANAGEMENT: Fever, Bacteremia and Septicemia. Cardinal Syumptom Complexes. Upper Respiratory Tract & Oral Infections. Lower Respiratory Tract Infections. Cardiac & Vascular Infections. Central Nervous System Infections. Genitourinary Tract Infections: Kidney and Urinary Tract, Reproductive Organs and Genital Tract. Gastrointestinal Tractinfections & Intoxications. Intra-Abdominal Infections. Skin & Soft Tissue Infections. Bone & Joint Infections. Eye Infections. Infections Related to Trauma. Infections of the Fetus and Newborn. Infections and Transplantation. Infections and Cancer. Infections Associated with Hospitalization. Infections Associated with Medical Devices. Infections in Patients with Deficient Defenses. Human Immunodeficiency Virus (HIV) and the Acquired Immunodeficiency Syndrome PART III ETIOLOGIC AGENTS of INFECTIOUS DISEASES: Bacterial Diseases: Gram-Positive Cocci, Gram-Negative Cocci, Gram-Positive Bacilli, Enterobacteriaceae: Gram-Negative Bacilli, Nonenterobacteriaceae: Gram-Negative Bacilli, Gram-Negative Coccobacilli, Treponemataceae (Spiral Organisms), Anaerobic Bacteria, Mycoplasma, Diseases of Possible Infectious or Unknown Etiology. Viral Diseases: DNA Viruses, Poxviridae, Herpesviridae, Adenoviridae, Papovaviridae, Hepadnaviridae, Parvoviridae, RNA Viruses: Reoviridae, Togaviridae, Flaviviridae, Bunyaviridae, Coronaviridae, Paramyxoviridae, Rhabdoviridae, Orthomyxoviridae, Filoviridae, Arenaviridae, Retroviridae, Picornaviridae, Caliciviridae. Mycoses. Human Parasites and Vectors: Protozoa, Nematodes, Cestodes, Intestinal, Tissue (Larval Forms) Trematodes, Arthropods PART IV LABORATORY DIAGNOSIS & THERAPY of INFECTIOUS DISE ASES: the Clinician & The Laboratory. Anti-Infective Therapy

608 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202413
20235,385
202211,558
202110,147
202010,069
201910,460