Topic
Transplantation
About: Transplantation is a research topic. Over the lifetime, 276584 publications have been published within this topic receiving 7961661 citations.
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TL;DR: This differentiation protocol provides a means of generating human oligodendroglial lineage cells in high purity, for use in studies of lineage development, screening assays of oligodendedrocytes and their progenitors, and treating neurodegenerative diseases and traumatic injuries to the adult CNS.
Abstract: Human embryonic stem cells (hESCs) demonstrate remarkable proliferative and developmental capacity. Clinical interest arises from their ability to provide an apparently unlimited cell supply for transplantation, and from the hope that they can be directed to desirable phenotypes in high purity. Here we present for the first time a method for obtaining oligodendrocytes and their progenitors in high yield from hESCs. We expanded hESCs, promoted their differentiation into oligodendroglial progenitors, amplified those progenitors, and then promoted oligodendroglial differentiation using positive selection and mechanical enrichment. Transplantation into the shiverer model of dysmyelination resulted in integration, differentiation into oligodendrocytes, and compact myelin formation, demonstrating that these cells display a functional phenotype. This differentiation protocol provides a means of generating human oligodendroglial lineage cells in high purity, for use in studies of lineage development, screening assays of oligodendroglial-specific compounds, and treating neurodegenerative diseases and traumatic injuries to the adult CNS.
592 citations
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TL;DR: The ethical acceptability of the study was gauged from the results of a broad information programme directed at the general public in Sweden, and from discussions with professionals including doctors, nurses, hospital chaplains, and judges.
591 citations
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TL;DR: This section of the 29th official International Society for Heart and Lung Transplantation (ISHLT) Registry report summarizes the current status of adult lung and heart-lung transplantation by reporting data on this international group of patients.
Abstract: This section of the 29th official International Society for Heart and Lung Transplantation (ISHLT) Registry report summarizes the current status of adult lung and heart-lung transplantation by reporting data on this international group of patients. The Registry contains data on 3,631 adult heart-lung and 39,835 adult lung transplants performed through June 30, 2011 from centers around the world. More detailed information is presented in the full slide set, which is available on the ISHLT Web site at www.ishlt.org/registries/.
591 citations
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TL;DR: Imatinib, an inhibitor of BCR-ABL tyrosine kinase, has revolutionised treatment of this disease, and is now recommended as standard treatment for chronic-phase CML.
591 citations
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TL;DR: The investigation of this cluster documents the transmission of West Nile virus by organ transplantation and suggests organ recipients receiving immunosuppressive drugs may be at high risk for severe disease after West Nileirus infection.
Abstract: Background In August 2002, fever and mental-status changes developed in recipients of organs from a common donor. Transmission of West Nile virus through organ transplantation was suspected. Methods We reviewed medical records, conducted interviews, and collected blood and tissue samples for testing with a variety of assays. Persons who donated blood to the organ donor and associated blood components were identified and tested for West Nile virus. Results We identified West Nile virus infection in the organ donor and in all four organ recipients. Encephalitis developed in three of the organ recipients, and febrile illness developed in one. Three recipients became seropositive for West Nile virus IgM antibody; the fourth recipient had brain tissue that was positive for West Nile virus by isolation and nucleic acid and antigen assays. Serum specimens obtained from the organ donor before and immediately after blood transfusions showed no evidence of West Nile virus; however, serum and plasma samples obtained...
590 citations