scispace - formally typeset
Search or ask a question
Topic

Transplantation

About: Transplantation is a research topic. Over the lifetime, 276584 publications have been published within this topic receiving 7961661 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Survival analysis showed that clinical profiles predict outcomes in HF and may be used to guide therapy and identify populations for future investigation.

590 citations

Journal ArticleDOI
01 Jul 2006-Medicine
TL;DR: A national registry of United States residents with XLA was established in 1999 to provide an updated clinical view of the disorder in a large cohort of patients and found that patients with a positive family history at the time of their birth were diagnosed before clinical symptoms developed.

590 citations

Journal ArticleDOI
TL;DR: To better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment, significant hurdles remain.
Abstract: Stem cell-based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can improve function by replacing the lost neurons and glial cells and by mediating remyelination, trophic actions, and modulation of inflammation. Endogenous neural stem cells are also potential therapeutic targets because they produce neurons and glial cells in response to injury and could be affected by the degenerative process. As we discuss here, however, significant hurdles remain before these findings can be responsibly translated to novel therapies. In particular, we need to better understand the mechanisms of action of stem cells after transplantation and learn how to control stem cell proliferation, survival, migration, and differentiation in the pathological environment.

590 citations

Journal ArticleDOI
25 Jul 2013-Blood
TL;DR: The results for adult umbilical cord blood transplantation have improved, with greater emphasis on cord blood units of sufficient cell dose and human leukocyte antigen match and with the use of double umbilicals Cord blood units and improved supportive care techniques.

589 citations

Journal ArticleDOI
TL;DR: Results are consistent with the contention that both myocyte and collagen compartments participate in the development of decompensated eccentric ventricular hypertrophy in the cardiomyopathic heart of ischemic origin.
Abstract: BACKGROUNDIschemic cardiomyopathy is characterized by myocyte loss, reactive cellular hypertrophy, and ventricular scarring. However, the relative contribution of these tissue and cellular processes to late failure remains to be determined.METHODS AND RESULTSTen hearts were obtained from individuals undergoing cardiac transplantation as a result of chronic coronary artery disease in its terminal stage. An identical number of control hearts were collected at autopsy from patients who died from causes other than cardiovascular disease, and morphometric methodologies were applied to the analysis of the left and right ventricular myocardium. Left ventricular hypertrophy evaluated as a change in organ weight, aggregate myocyte mass, and myocyte cell volume per nucleus showed increases of 85%, 47%, and 103%, respectively. Corresponding increases in the right ventricle were 75%, 74%, and 112%. Myocyte loss, which accounted for 28% and 30% in the left and right ventricles, was responsible for the difference in th...

589 citations


Network Information
Related Topics (5)
Stem cell
129.1K papers, 5.9M citations
88% related
Cytokine
79.2K papers, 4.4M citations
83% related
T cell
109.5K papers, 5.5M citations
82% related
Inflammation
76.4K papers, 4M citations
82% related
Immune system
182.8K papers, 7.9M citations
82% related
Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202413
20235,385
202211,558
202110,147
202010,069
201910,460