Showing papers on "Triazene published in 1976"
TL;DR: The identification of BAEN as the principal azo derivative of the excreted triazene metabolites is in full agreement with the proposed in vivo activation of 3,3-dimethyl-1-phenyltriazene (DMPT) to a carcinogenic methylating agent.
30 citations
TL;DR: In this article, one-bond nitrogen-nitrogen coupling constants are reported for a series of triazenes and the results are compatible with the significant contribution of a structure such as II.13C and 15N-NMR.
Abstract: 13C- and 15N-NMR. spectra have been measured for a series of triazenes. The results are compatible with the significant contribution of a structure such as II. One-bond nitrogen-nitrogen coupling constants are reported.
27 citations
01 Jan 1976
TL;DR: In this paper, urinary metabolites of 3.3-dimethyl-1-phenyltriazene and its para chlorinated congener, 1-(4-chlorophenyl)-3.3dimethyltrieazene, were identified.
Abstract: It is generally accepted that the inhibition of neoplasia by triazenes depends on their conversion into reactive intermediates. The triazenes are dealkylated by the hepatic microsomal enzymes (1) and it has been suggested that degradation of the drugs to alkylating agents is an essential step in their activation (2). Since alternative modes of activation cannot be excluded and metabolism of this class has been little investigated, urinary metabolites of 3.3- dimethyl-1-phenyltriazene and its para chlorinated congener, 1-(4-chlorophenyl)-3.3-dimethyltriazene, were identified. Both compounds are known to increase the life-span of mice bearing the TLX lymphoma by about 60% at their optimal doses (3, 4).
7 citations
TL;DR: In this article, the pseudooctahedral equilibrium of cobalt(II) and nickel(II)-2Ni complexes of triazene 1-oxides derived from amino pyridines is investigated.