Showing papers on "Triazene published in 1979"
TL;DR: It is conceivable that this metabolite represents a stabilised carrier form of the biologically-active triazene that transports the methylating agent from its site of formation to its ultimate target.
26 citations
20 citations
TL;DR: Induced mutation frequency is not strongly influenced by modifications in the genetic background of the S. typhimurium Ames tester strains, but is mildly enhanced by the addition of a pool of amino acids to the plating medium and is strongly enhanced by liquid preincubation before plating.
Abstract: An aryl-monoalkyl triazene, methyl-p-tolyl triazene (MTT) and a cyclic triazene (delta2-triazoline) are direct-acting mutagens for Salmonella typhimurium bacteria and for cell-free Hemophilus influenzae DNA. MTT causes reversion of the hisG46 base-substitution mutation, but no reversion of the hisD3052 frameshift mutation. Induced mutation frequency is not strongly influenced by modifications in the genetic background of the S. typhimurium Ames tester strains, but is mildly enhanced by the addition of a pool of amino acids to the plating medium and is strongly enhanced by liquid preincubation before plating.
9 citations
TL;DR: A good trend is indicated that substitution of the ring with deactivating atoms and extent of demethylation compare well, and it is expected that Triazenes, deactivated with halogene atoms in the phenylring, were better demethylated.
Abstract: The oxidative N-demethylation was investigated for a series of 3,3-dimethyl-l-phenyl-triazenes. Triazenes, deactivated with halogene atoms in the phenylring, were expected to be better demethylated. The results do indicate a good trend that substitution of the ring with deactivating atoms and extent of demethylation compare well. The percentages of demethylation were: For 3,3-dimethyl-l-phenyltriazene, 45%; for 3,3-dimethyl-l (4-chlor-phenyl)-triazene, 92%; for 3,3-dimethyl-l(4-bromophenyl)triazene, 89%; for 3,3-dimethyl-l-(2,4,6-trichlorophenyl)triazene, 122%; and for 3,3-dimethyl-l-l-(2,4,6-tribromophenyl)triazene, 85%.
5 citations
Patent•
30 Jan 1979
TL;DR: A novel triazene compound which upon thermal or photochemical decomposition provides free radicals for polymer initiation and methods using same is described in this article, where the free radicals are used for polymer synthesis.
Abstract: A novel triazene compound which upon thermal or photochemical decomposition provides free radicals for polymer initiation and methods using same.
5 citations