Topic
Triazene
About: Triazene is a research topic. Over the lifetime, 759 publications have been published within this topic receiving 8714 citations. The topic is also known as: Triazene cleavage & 1-triazene.
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TL;DR: In this paper , a two-step procedure starting from 5-acetyl-3-N-(4-sulfamoylphenyl)-2-imino-1,3,4-thiadiazoline derivatives were designed as human carbonic anhydrase inhibitors (hCAIs) to develop robust and novel anticancer agents.
TL;DR: In this article , a set of aryltriazene bearing different substituents are synthesized and characterized in solution by means of different analytical techniques, showing a large dependence of required doses and UV-vis spectrum evolution on the substituent position and character.
Abstract: • New aryltriazenes are synthesized and fully characterized in solution by means of different analytical techniques. • The photoreactivity depends on the kind and position of the chemical substituents of the phenyl ring and on the solvent used. • The photoproducts are evaluated using GC-MS and they depends on the solvent used. • The light induced reaction of the nitro derivative is performed in polymer matrices. • The reactivity changes with the polymer used. Triazenes are molecular systems that undergo a photolysis with the evolution of molecular nitrogen. A set of aryltriazene bearing different substituents are synthesized and characterized. The photoreaction is studied in solution by means of UV-vis spectroscopy showing a large dependence of required doses and UV-vis spectrum evolution on the substituent position and character. The structural changes upon the photolysis are also probed using vibrational spectroscopy (IR and Raman). Moreover, GC-MS spectroscopy is employed to retrieve the structure of the main photoproducts. The most promising derivative, in terms of stability and band position is incorporated in different polymer matrices, both thermosetting and thermoplastic; its photoreaction is studied in correlation with the polymer structure.
TL;DR: In this paper, the Aryldiazoniumsalze (I) reagieren with Cytisin (II) im alkalischen pH-Bereich zu den Triazenen (III ).
Abstract: Die Aryldiazoniumsalze (I) reagieren mit Cytisin (II) im alkalischen pH-Bereich zu den Triazenen (III ).
TL;DR: The hydrosoluble triazene derivatives of phenylacetic, phenylbutyric and cinnamic acid have been synthesized and their logP and pKa values were simultaneously determined according to a multiparametric fitting of potentiometric data.
Abstract: The hydrosoluble triazene derivatives of phenylacetic, phenylbutyric and cinnamic acid have been synthesized and their logP and pKa values were simultaneously determined according to a multiparametric fitting of potentiometric data. The antitumor activity caused by the synthesized compounds in mice bearing either Lewis lung carcinoma or TLX5 lymphoma was evaluated and discussed in comparison with the parent compound (p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK, CAS 70055-49-1). The tested compounds were at least as active as DM-COOK, the cinnamic and the phenylacetic derivatives being the more active compounds in mice bearing TLX5 lymphoma and Lewis lung carcinoma, respectively.
TL;DR: In this paper, the roles of the acid anion and the water molecule in the hydrolysis of triazenes have been investigated and an analytical expression has been obtained from the analytical expression which agrees with the experimental results.
Abstract: The kinetics and nature of the end products of the acid decomposition of triazenes (R′-N=N-NHR″, where R′ is aryl, and R” is aryl or alkyl) in aqueous ethanolic solutions of varying composition have been studied. A hydrolysis mechanism which includes protonation of the triazene molecule (R′-N+H=NH-R″), formation of an σN-transition stafte (R′-N=N-N+H2-R″), and dissociation of this state has been proposed to explain the literature data and the opposite ionic effects observed in the present study. This mechanism explains the roles of the acid anion and the water molecule in the hydrolysis of triazenes. An analytical expression has been obtained from the hydrolysis constant which agrees with the experimental results.