Topic
Triazene
About: Triazene is a research topic. Over the lifetime, 759 publications have been published within this topic receiving 8714 citations. The topic is also known as: Triazene cleavage & 1-triazene.
Papers published on a yearly basis
Papers
More filters
TL;DR: Dissection studies of selected brain regions show that at 3 h post injection (R,S)-[125I]IQNB prepared by all three methods have indistinguishable % dose g-1 values in all brain regions studied, which indicates a high radiochemical yield of a high specific activity product.
6 citations
TL;DR: In this article, the triazene oxide sodium salts with 3,3-dialkyl-1,chloromethoxy-1-triazene 2-oxides produces a complex mixture of product bearing the oxytriazenes moieties of the starting alkoxy-3-methyl-3-(methylthiomethyl)-1-oxide bonded with the methylene group as a key structural fragment.
Abstract: 1-Alkoxy-3-methyl-1-triazene 2-oxide sodium salts react with chloromethyl methyl sulfide to give a mixture of 1-alkoxy-3-methyl-3-(methylthiomethyl)-1-triazene 2-oxides and 3-alkoxy-1-methyl-3-(methylthiomethyl)-1-triazene 2-oxides. The reaction of these triazene oxide sodium salts with 3,3-dialkyl-1-chloromethoxy-1-triazene 2-oxides produces a complex mixture of product bearing the oxytriazene moieties of the starting alkoxy-1-triazene 2-oxides bonded with the methylene group as a key structural fragment.
6 citations
TL;DR: The title 4,4'-disubstituted diphenyl-1,3-triazines, C14H15N3, C12H9ClFN3, (II), and C13H12FN 3, (III), each contain a triazene group (-N=N-NH-) having an extended conformation.
Abstract: The title 4,4'-disubstituted diphenyl-l,3-triazines, C 14 H 15 N 3 , (I), C 12 H 9 ClFN 3 , (II), and C 13 H 12 FN 3 , (III), each contain a triazene group (-N=N-NH-) having an extended conformation The dihedral angles between the two benzene rings in (I), (II) and (III) are 43, 34 and 65°, respectively The molecules are almost entirely planar, with maximum deviations from the mean planes of 01087 (2), -01072(7) and 01401 (3) A, respectively In each compound, the molecules are linked by N-HN hydrogen bonds to form chains and pack similarly in the crystal structures
6 citations
TL;DR: Key physicochemical properties align for optimal CNS penetration, highlighting the potential of these effective triazene based-hybrids for enhanced anticancer chemotherapy.
6 citations
TL;DR: In this article, a means of generating an N-alkyl-N-arylaminodiazonium ion, which then loses nitrogen to form a reactive aryl nitrenium intermediate, is described.
Abstract: A means of generating an N-alkyl-N-arylaminodiazonium ion, which then loses nitrogen to form a reactive aryl nitrenium intermediate, is described. In this sequence, a set of triazenyl acetonitriles was synthesized by nucleophilic addition of a nitrile anion to an aryl azide followed by temperature-dependent alkylation at either of two nucleophilic triazenyl nitrogen atoms. An α,α-disubstituted acetonitrile and N-arylaminodiazonium moiety (or aryl nitrenium ion upon loss of N2) are embedded in the resulting 1,3,3-trisubsituted triazene, which undergoes liberation and recombination of these two components under acidic conditions to yield an α-arylated acetonitrile containing an all-carbon-quaternary center. We propose that the N-alkyl-N-arylaminodiazonium ion loses nitrogen to generate an aryl nitrenium species, which then reacts with an α,α-disubstituted acetonitrile either at the para- or meta-position of the aromatic ring to afford p-alkylaminoaryl acetonitrile derivatives or 3,3-substituted 1-methylindolin-2-imines, depending on the substrates and conditions.
6 citations